Vaporized hydrogen peroxide (VHP) or hydrogen peroxide vapor (HPV) is gaining popularity and we are seeing rapid expansion of its use for everything from biological safety cabinets to animal rooms.

The ACGIH, OSHA, and the National Institute of Occupational Safety and Health (NIOSH) have all set an average daily occupational exposure limit of 1 ppm. NIOSH, and at least one material safety data sheet (MSDS), recommends the use of supplied air respirators or a self-contained breathing apparatus for concentrations above 10 ppm.

Concentrations above 75 ppm are considered immediately dangerous to life and health (IDLH). With typical decontamination levels of 1000 ppm or more, we must ensure worker safety. The major manufacturers of VHP equipment offer specific training for both operators and safety. These sessions are highly recommended and, in fact, may even be required with purchase by some manufacturers. Operators should check the equipment for damage and proper function prior to each use. Safeguards, in the form of specialized lock out/tag out procedures, must be in place and strictly followed during the decontamination cycle. All workers with access to the equipment enclosure or room area, as well as those working in close proximity, must have hazard awareness training on hydrogen peroxide. The minimum PPE for operators includes full cover protective clothing (e.g. Tyvek), rubber gloves, and chemical splash goggles.

VHP has many advantages over widely used sterilants, like formaldehyde and ethylene oxide, but it is not without hazards. Studies have shown it to be very effective for bio-decontamination, compatible with most materials that include electronics and sensitive equipment, and cost effective. Combining comprehensive health and safety procedures with VHP can prove an efficient decontamination technology.

From: VHP Safety Basics by the Safety Guys