For years, researchers have investigated the reasons for problkems with wound healing in diabetics. While many factors contribue, the specific molecular events have remained unclear, and there are few therapies available to treat these stubborn wounds.
Newly discovered genetic variations linked to autism spectrum disorder (ASD) disrupt the...
Scientists studying hatchling fish have made a new advance in studying a chemical in the brain...
Coating the mouth with BPA-containing food, like soup, does not lead to higher than expected...
Starting from human skin cells, researchers have created human insulin-producing cells that respond to glucose and correct blood-sugar levels in diabetic mice. The findings may represent a first step toward developing patient-specific cell replacement therapy for type 1 diabetes.
Does sanitation stump you? Have a cleaning conundrum? Don't ask your co-worker, ask an expert! ALN is launching a new online-only column featuring an industry expert answering your burning questions about cleaning and sanitation.
People bitten by a rabid animal have only a very brief window of time to seek medical attention before the virus takes hold in the central nervous system, at which point, the disease is nearly always fatal. A new study has successfully tested a treatment on mice that cures the disease, even after it has spread to the brain.
Researchers have used human pluripotent stem cells to generate new hair. The study represents the first step toward the development of a cell-based treatment for people with hair loss.
Researchers have shown that a micromotor fueled by stomach acid can take a bubble-powered ride inside a mouse. These tiny motors, each about one-fifth the width of a human hair, may someday offer a safer and more efficient way to deliver drugs or diagnose tumors.
Studies show mice that receive a supplement of the “appetite hormone” ghrelin increase their sexual activity. Whether the hormone has the same impact on humans is unknown - but if it does, the researchers may have found the key to future treatments for sex abuse.
Scientists have identified a circuit in the brains of mice that regulates thirst. When a subset of cells in the circuit is switched on, mice immediately begin drinking water, even if they are fully hydrated. A second set of cells suppresses the urge to drink.
In the battle against ovarian cancer, researchers have created the first mouse model of the worst form of the disease and found a potential route to better treatments and much-needed diagnostic screens.
A number of therapies are available to help drug users quit, but addiction is extremely tough to beat. Scientists are working on vaccines to neutralize the high-inducing effects of recreational drugs, like cocaine. A new study has hit upon an approach that might annul cocaine's additive buzz.
Resistance of leukemia cells to contemporary chemotherapy is one of the most formidable obstacles to treating acute lymphoblastic leukemia, the most common form of childhood cancer. Now researchers have designed and developed a new protein-based therapy they believe will prove highly effective against drug-resistant leukemia cells.
A study shows that decreasing the number of A2A adenosine receptors in a particular type of brain cells called astrocytes improved memory in healthy mice. What’s more, reducing receptor levels also prevented memory impairments in a mouse model of Alzheimer’s disease.
Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). Their precise molecular cause has never been determined. Now, cardiovascular scientists have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.
Use of the same antiangiogenesis drugs that have improved treatment of some cancers could also help surmount persistent difficulties in treating tuberculosis.
Immune cells known as mast cells play a primary role in allergic reactions. Mast cells are activated by immunoglobulin E (IgE) antibodies and release inflammatory chemicals like histamine. Some compounds, however, can activate mast cells without interacting with IgE antibodies, triggering a so-called “pseudo-allergic” reaction. These substances, known as basic secretagogues, include many drugs that can cause allergic reactions.
Stress hormones in the mother can affect fetal development, according to a study published in The Journal of Physiology. Researchers found that increased levels of glucocorticoid stress hormones in pregnant mice caused the mother to eat more but reduced the ability of the placenta to transport glucose to her fetus.