For rats bearing human breast tumors, exposure to dim light at night made the tumors resistant to the standard breast cancer chemotherapy doxorubicin, but giving the rats a melatonin supplement during the dim-light exposure at night prevented resistance development and promoted tumor regression.
Ongoing research is investigating the connection between initial seizures and the onset of...
When it comes to using marijuana, new research involving mice suggests that just because you can...
Cancer vaccines have recently emerged as a promising approach for killing tumor cells...
Researchers have described a new approach to discovering potential cancer treatments that requires a fraction of the time needed for more traditional methods. They used the platform to identify a novel antibody that is undergoing further investigation as a potential treatment for breast, ovarian and other cancers.
Check your mailbox next week to see the new ALN Magazine! With this redesign, we are now able to better serve you, our readers. The October issue of ALN will feature a smaller size and updated design.
Engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA, and DNA, to human patients.
Scientists have discovered that a gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain. The researchers found large droplets of triglycerides within the neurons of mice modeling the disease.
In the second of two papers outlining new gene-therapy approaches to treat a rare disease called MPS I, examined systemic delivery of a vector to replace the enzyme IDUA, which is deficient in patients with this disorder.
The idea of mapping the brain is not new. Researchers have known for years that the key to treating, curing, and even preventing brain disorders is to understand how the brain records, processes, stores, and retrieves information. Now, new research makes a major contribution to efforts to navigate the brain.
Researchers have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer’s disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition.
Children with DiGeorge syndrome often have facial defects that include an undeveloped chin, heavy eyelids, and ears that are rotated back. To understand how genes cause DiGeorge syndrome's complex developmental problems, researchers have turned to zebrafish as a model.
A spice commonly found in curries may boost the brain's ability to heal itself. A German study suggests a compound found in turmeric could encourage the growth of nerve cells thought to be part of the brain's repair kit.
Physical exercise has many beneficial effects on human health, including the protection from stress-induced depression. However, until now the mechanisms that mediate this protective effect have been unknown.
A triple-punch of antibodies both prevented hepatitis C infection and wiped out the disease after it had established itself in laboratory mice. Instead of delivering the three antibodies directly, researchers administered a genetic "instruction set" that, once in a cell, developed into antibodies that target the portions of the virus that do not mutate.
Check your mailbox for the new ALN Magazine! With this redesign, we are now able to better serve you, our readers. One of the new things the October issue of ALN will feature is fresh, current content and columns.
Scientists have shown that the brain can temporarily disconnect information about past experience from decision-making circuits, thereby triggering random behavior. In the study, rats playing a game for a food reward usually acted strategically, but switched to random behavior when they confronted a particularly unpredictable and hard-to-beat competitor.
Researchers have created a new mouse model to simplify application of the CRISPR-Cas9 system for in vivo genome editing experiments.
Scientists have identified a protein in the human intestine that helps to protect against attack from opportunistic bacteria that strike when our defences are down. The protein receptor is activated during illness, producing a force field on the gut's surface made of a sugary substance that encourages the growth of protective bacteria.