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The Lead

Targeting Immunosuppression in Brain Tumors

January 11, 2016 | by Nora Dunne, Northwestern University | Comments

The standard of care for adult patients with glioblastoma includes surgical resection, radiotherapy and chemotherapy, but even with those aggressive treatments median survival is only just over a year. The goal of the researchers is to understand how manipulating immunosuppressive pathways can increase survival when combined with existing therapies.


New NIH Policy Requires Researchers to Evaluate 'Sex as a Biological Variable'

February 12, 2016 10:55 am | by Lauren Scrudato, Associate Editor, Laboratory Equipment | Comments

As more drugs hit the market, instances of women having complications from tested and approved drugs prompted the National Institutes of Health and Congress to require that women be included in research involving human subjects, officially named the Revitalization Act.


Blocking Stress Protein Relieves Chronic Pain in Mice

February 12, 2016 9:42 am | Comments

A group of drugs being developed to treat mood disorders could also relieve chronic pain, finds new UCL (University College London) research funded by the Medical Research Council.


Alcohol Also Damages the Liver by Allowing Bacteria to Infiltrate

February 12, 2016 9:42 am | by Heather Buschan, Ph.D., University of California, San Diego | Comments

Alcohol itself can directly damage liver cells. Now researchers at University of California, San Diego School of Medicine report evidence that alcohol is also harmful to the liver for a second reason — it allows gut bacteria to migrate to the liver, promoting alcohol-induced liver disease.


Vinegar Could Potentially Help Treat Ulcerative Colitis

February 12, 2016 9:41 am | Comments

Vinegar is the perfect ingredient for making tangy sauces and dressings. Now, researchers report in ACS' Journal of Agricultural and Food Chemistry that the popular liquid could also help fight ulcerative colitis, an inflammatory bowel disease that research suggests is related to the gut microbiome.


Fish Oil Combats Alzheimer's Disease in Mouse Model

February 12, 2016 9:41 am | Comments

Despite enormous effort to find out an efficient treatment, current pharmacological interventions are limited to a few drugs that alleviate symptoms but do not slow down the underlying disease processes of Alzheimer's.


Search for Zika Virus Cure Begins with Research in Non-Human Primates

February 12, 2016 9:40 am | by Chris Barncard, University of Wisconsin-Madison | Comments

Some of the first experiments studying Zika virus in monkeys have begun, conducted by a broad UW–Madison team that includes the Wisconsin National Primate Research Center and expertise in infectious disease, pregnancy and neurology.


A Sugary Diet During Pregnancy Leads to Obese Offspring

February 11, 2016 11:14 am | by Elizabeth Doughman, Editor-in-Chief | Comments

Pregnant mice that received a high fructose diet was more likely to give birth to offspring that were hypertensive, insulin resistant, and obese, according to a study presented at the Society for Maternal-Fetal Medicine's annual meeting.


Researchers Resolve Longstanding Issue of Components Needed to Regenerate Muscle

February 11, 2016 9:32 am | by Susan Gammon, Ph.D., Sanford-Burnham Prebys Medical Discover Unit | Comments

Researchers have conclusively identified the protein complex that controls the genes needed to repair skeletal muscle. The discovery clears up deep-rooted conflicting data and will now help streamline efforts towards boosting stem cell-mediated muscle regeneration.


Study Shows Promising Safety Results for Anti-aging Drug

February 11, 2016 9:32 am | Comments

Previous studies on the metabolic side effects of rapamycin have made it unclear whether the drug is safe as a long-term treatment. A recent study showed minimal metabolic side effects after continuous, long-term treatment with encapsulated rapamycin in a marmoset (monkey) model.


Starfish Reveal the Origins of Brain Messenger Molecules

February 11, 2016 9:32 am | Comments

Publishing in the Royal Society journal Open Biology, the team led by Professor Maurice Elphick at QMUL’s School of Biological and Chemical Sciences report 40 new neuropeptide genes discovered for the first time in the common European starfish Asterias rubens.


Extremophile Fish's Adaptation to Pollution May Lead to Biomedical Applications

February 11, 2016 9:31 am | by Eric Sorensen, Washington State University | Comments

A Washington State University biologist has found the genetic mechanism that lets a fish live in toxic, acidic water. The discovery opens new insights into the functioning of other “extremophiles” and how they adapt to their challenging environments.

Eggs May Help Diabetics with a Vitamin D Deficiency

February 11, 2016 9:31 am | Comments

A simple change in diet could boost vitamin D levels for millions of Americans suffering from Type 2 diabetes, according to new research from Iowa State University published in the Journal of Agricultural and Food Chemistry.


Gut Environment Could Reduce Severity of Malaria

February 10, 2016 10:19 am | Comments

Microorganisms in the gut could play a role in reducing the severity of malaria, according to a new study co-authored by UT researchers.


Aerobic Exercise Helps Rats Learn

February 10, 2016 10:12 am | Comments

It may be possible to increase the neuron reserve of the hippocampus – and thus improve preconditions for learning – by promoting neurogenesis via sustained aerobic exercise such as running.


Wbp2 Gene Implicated in Deafness

February 10, 2016 9:58 am | Comments

A new study reports that the loss of Wbp2 expression leads to progressive high-frequency hearing loss in mouse as well as in two clinical cases of children with deafness with no other obvious features.



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