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Find ALN at AALAS

October 17, 2014 | by Elizabeth Doughman | Comments

Don't forget to come find ALN in San Antonio! Stop by booth 1240 at AALAS October 20-22 to subscribe to ALN Magazine and ALN World, pick up the latest issues, or to chat with an Editor. We look forward to seeing you there!         

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Focusing In on a Decades Old Mystery

October 21, 2014 11:41 am | Comments

Elvis did it, Michael Jackson did it, and so do the mitochondria in our cells. They shake. While Elvis and Michael shook for decades before loud and appreciative audiences, mitochondrial oscillations have quietly bewildered scientists for more than 40 years. Now, an NIH team has imaged mitochondria for the first time oscillating in a live animal - in this case, the salivary glands of laboratory rats.

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Rat Study Helps to Understand Epilepsy, Other Brain Disorders

October 21, 2014 12:00 am | Comments

Researchers have used graphene, a two-dimensional form of carbon only one atom thick, to fabricate a new type of microelectrode that solves a major problem for investigators looking to understand the intricate circuitry of the brain. The team performed calcium imaging of hippocampal slices in a rat model with both confocal and two-photon microscopy, while also conducting electrophysiological recordings.

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Therapeutic Saline May Treat Alzheimer's Disease, Other Dementias

October 20, 2014 12:33 pm | Comments

Revalesio Corp. and Rush University Medical Center's Department of Neurological Sciences have published findings from two research studies that demonstrate the potential for RNS60 to treat Alzheimer's disease and other forms of dementia by protecting neuronal function, restoring neuronal connections and promoting neuronal plasticity.

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Drug May Offer Alternative to Chemo for Blood Cancer

October 20, 2014 12:20 pm | Comments

Researchers say that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated quarter of the 500 U.S. adolescents and young adults diagnosed each year with this aggressive disease fail to respond to standard chemotherapy drugs that target cancer cells.

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Mature Human Intestinal Tissue Formed in Mice

October 20, 2014 12:13 pm | Comments

Researchers have successfully transplanted “organoids” of functioning human intestinal tissue grown from pluripotent stem cells in a lab dish into mice – creating an unprecedented model for studying diseases of the intestine. The findings could eventually lead to bioengineering personalized human intestinal tissue to treat gastrointestinal diseases.

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Male Mice More Likely to Become Obese

October 18, 2014 2:44 pm | Comments

Cedars-Sinai Diabetes and Obesity Research scientists and a team of international investigators found that the brains of male laboratory mice exposed to the same high-fat diet as their female counterparts developed brain inflammation and heart disease that were not seen in the females.

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Researchers Gain Control Over Stem Cell Differentiation in Mice

October 18, 2014 2:32 pm | by Debra Kain | Comments

Progenitor cells have the ability to differentiate into specific types of cells, and can migrate to the tissue where they are needed. Their potential to differentiate depends on their type and niche. The tissue-engineering technique discovered required only a simple polymer to deliver the cells, and multiple cellular groupings show the ability to generate a replacement organ with all cell layers and functions.

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In a discovery that might ring true even for some humans, researchers have shown that male brains – at least in nematodes – will suppress the ability to locate food in order to instead focus on finding a mate.

Male Worms Rewired to Prefer Food to Sex

October 17, 2014 1:11 pm | by Univ. of Rochester Medical Center | Comments

In a discovery that might ring true even for some humans, researchers have shown that male brains — at least in nematodes — will suppress the ability to locate food in order to instead focus on finding a mate.           

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FDA Issues Recommendations for Animal Drug Sponsors

October 17, 2014 12:48 pm | by FDA | Comments

The U.S. Food and Drug Administration issued today draft Guidance for Industry #227: Two-Phased Chemistry, Manufacturing, and Controls (CMC) Technical Sections, with recommendations for ways animal drug sponsors can submit chemistry, manufacturing, and controls (CMC) data to the agency to improve the efficiency of the New Animal Drug Application (NADA) review process.

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Respiratory Syncytial Virus causes severe respiratory tract infections and worldwide claims the lives of 160,000 children each year. Scientists have succeeded in developing a promising vaccination strategy to counteract this common virus infection.

New Perspectives for Development of RSV Vaccine

October 17, 2014 12:38 pm | by VIB/Univ. of Gent | Comments

Respiratory Syncytial Virus causes severe respiratory tract infections and worldwide claims the lives of 160,000 children each year. Scientists have succeeded in developing a promising vaccination strategy to counteract this common virus infection. 

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Researchers have found that male and female brains respond in remarkably   different ways to high-fat meals. Those differences in the brain lead to   greater inflammation and increased health risks in males that indulge on fatty foods in comparison to f

Brains of Male Mice Have Greater Response to Fat

October 17, 2014 12:26 pm | by Cell Press | Comments

Researchers have found that male and female brains respond in remarkably different ways to high-fat meals. Those differences in the brain lead to greater inflammation and increased health risks in males that indulge on fatty foods in comparison to females, a new study in mice shows. 

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Across the animal kingdom, it’s not uncommon for pregnancy to change an   expectant mom’s behavior. Even female flies have their own rudimentary way of   “nesting,” which appears to be brought on by the stretch of their egg-filled abdomens rather than t

Pregnant Feeling Makes Flies Nest

October 17, 2014 12:07 pm | by Duke Univ. | Comments

Across the animal kingdom, it’s not uncommon for pregnancy to change an expectant mom’s behavior. Even female flies have their own rudimentary way of “nesting,” which appears to be brought on by the stretch of their egg-filled abdomens rather than the act of mating.

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Why Airways Close Up During Asthma Attacks

October 16, 2014 2:26 pm | by Mallar Bhattacharya, MD | Comments

The researchers found that mice lacking the gene IQGAP1, which codes for a protein expressed in airway smooth muscle, had increased resistance to airflow during mechanical ventilation; they then found that rings of airway dissected from IQGAP1-knockout mice contract much more than those from normal mice. This data suggests that the IQGAP1 protein normally prevents airway contraction.

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Existing Rabies Vaccines May Protect Against Ebola

October 16, 2014 2:15 pm | Comments

The experimental vaccines—based on rabies virus vaccines currently used in people and in animals—contain either a killed or a live, attenuated rabies virus engineered to produce an Ebola protein. The killed, or inactivated, vaccine is being developed to prevent rabies and Ebola infection in people, while the live, attenuated vaccine is intended for use in African wildlife to help prevent Ebola virus transmission from animals to people.

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Fibroblasts Speed Heart Attack Recovery in Mice

October 16, 2014 1:57 pm | Comments

Researchers from the UNC School of Medicine have discovered that cells called fibroblasts, which normally give rise to scar tissue after a heart attack, can be turned into endothelial cells, which generate blood vessels to supply oxygen and nutrients to the injured regions of the heart, thus greatly reducing the damage done following a heart attack.

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