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The Lead

Study IDs New Targets for Reducing Nerve Pain

March 2, 2016 | by Hiroshima University | Comments

A specific molecule involved in maintaining pain after a nerve injury has been identified and blocked in mice by Hiroshima University researchers. These results reveal a promising therapeutic strategy for treating neuropathic pain.


"Fireflies" Light the Way to Understanding Female HIV Transmission

April 29, 2016 9:55 am | by Marla Paul, Northwestern University | Comments

Finding the vulnerable points where HIV enters the female reproductive tract is like searching for needles in a haystack. But Northwestern Medicine scientists have solved that challenge by creating a glowing map of the very first cells to be infected with a HIV-like virus.


Probiotics Stop Menopause-like Bone Loss in Mice

April 29, 2016 9:45 am | Comments

Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers at Emory University School of Medicine and Georgia State University have shown.


Nanoparticles Hold Promise As Double-edged Sword Against Genital Herpes

April 29, 2016 9:36 am | by Sharon Parmet, University of Illinois at Chicago | Comments

An effective vaccine against the virus that causes genital herpes has evaded researchers for decades. But now, researchers from the University of Illinois at Chicago working with scientists from Germany have shown that zinc-oxide nanoparticles shaped like jacks can prevent the virus from entering cells, and help natural immunity to develop.


Analysis of Dog Genome Will Provide Insight Into Human Disease

April 29, 2016 9:32 am | Comments

An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies -- according to a new study led by The Genome Analysis Centre (TGAC).


Serotonin Could Be Clue to Understanding SIDS

April 29, 2016 9:26 am | Comments

Although safe sleeping environments and reduction of behaviours associated with an increased risk of SIDS have reduced the number of events, SIDS and Asphyxia (lack of oxygen) remain among the most common causes of death in infants between the age of one month and one year.


Acupuncture Aids Brain Regeneration in Animal Model of Alzheimer's Disease

April 28, 2016 11:41 am | Comments

Researchers testing the potential positive effects of "micro-injury" by brief insertion of a small needle into the hippocampal region of mice modeled with Alzheimer's disease (AD) have found that the procedure not only stimulated the hippocampus into regenerative activity, but also reduced beta-amyloid plaques, a hallmark of AD.


Researchers Find Brain Circuit That Controls Binge Drinking

April 28, 2016 11:30 am | Comments

Researchers at the University of North Carolina at Chapel Hill have identified a circuit between two brain regions that controls alcohol binge drinking, offering a more complete picture on what drives a behavior that costs the United States more than $170 billion annually and how it can be treated.


MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment

April 28, 2016 11:07 am | Comments

Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.


Common Steroid Shows Promise in Healing Damaged Newborn Lungs

April 28, 2016 9:39 am | Comments

Research from Ann & Robert H. Lurie Children's Hospital of Chicago conducted in mice shows the drug hydrocortisone -- a steroid commonly used to treat a variety of inflammatory and allergic conditions -- can also prevent lung damage that often develops in premature babies treated with oxygen.


Memory Consolidation in the Brain During Rest Finally Understood

April 27, 2016 2:44 pm | by Elizabeth Doughman, Editor-in-Chief | Comments

The brain transfers memories from one part of the brains of rats to another during rest, a process important for memory consolidation. This new study from researchers at University College London may help further the understanding of amnesiac conditions, such as Alzheimer's disease.


Research Examines Link Between Gut Bacteria, PTSD

April 27, 2016 11:04 am | Comments

Could bacteria in your gut be used to cure or prevent neurological conditions such as post-traumatic stress disorder (PTSD), anxiety or even depression? Two researchers sponsored by the Office of Naval Research (ONR) think that’s a strong possibility.


Changes in Skin Microbiome in Dogs Could Lead to Antibiotic-free Therapies for Eczema

April 27, 2016 9:30 am | Comments

Atopic dermatitis (AD), a chronic inflammatory skin condition and the most common form of eczema, is estimated to afflict as much as 10 percent of the U.S. population. How AD arises isn’t yet fully understood, but a new study has uncovered important insights about the association of AD in dogs compared to humans.


GI Problems in Autism May Originate in Genes

April 27, 2016 9:30 am | Comments

Researchers at Columbia University Medical Center (CUMC) have found evidence in mice that, for some types of autism, gastrointestinal difficulties may originate from the same genetic changes that lead to the behavioral and social characteristics of the condition.


Exposure to Infection Makes Lab Mice More Human

April 27, 2016 9:29 am | by Elizabeth Doughman, Editor-in-Chief | Comments

Infecting laboratory mice with common pathogens changed their immune systems to better resemble those found in adult humans, according to a study published April 20 in Cell Host & Microbe. This study may contradict the belief that sterile housing is best for lab animals.


Protein Maintains a Healthy Heart in Older Mice

April 26, 2016 10:57 am | by Elizabeth Doughman, Editor-in-Chief | Comments

There is a way to improve heart function, which can decrease with age, according to a study in mice published in the Proceedings of the National Academy of Sciences. This discovery is the result of an international collaboration between Cornell University and scientists in Switzerland.



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