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The Lead

Protecting Us From Our Cells

October 22, 2014 | Comments

Our immune system defends us from harmful bacteria and viruses, but, if left unchecked, the cells that destroy those invaders can turn on the body itself, causing auto-immune diseases like type-1 diabetes or multiple sclerosis. A molecule called insulin-like growth factor-1 boosts the body’s natural defense against this ‘friendly fire.’



Lambs Advance Treatment for Respiratory Syncytial Virus in Infants

October 24, 2014 10:05 am | Comments

Veterinary research involving lambs at Iowa State University is helping to advance new treatments to a common virus in humans that sometimes poses a serious threat to newborns.             


Ebola Vaccine Could Have Been Ready 10 Years Ago

October 24, 2014 9:52 am | by Denise Grady | Comments

Almost a decade ago, scientists from Canada and the United States reported that they had created a vaccine that was 100 percent effective in protecting monkeys against the Ebola virus. The results were published in a respected journal, and health officials called them exciting.


Stress-related Inflammation May Increase Risk for Depression

October 23, 2014 5:02 pm | Comments

Preexisting differences in the sensitivity of a key part of each individual’s immune system to stress confer a greater risk of developing stress-related depression or anxiety, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published October 20 in the Proceedings of the National Academy of Sciences (PNAS). 


ETC Sterilization Systems Receives Control System Contract

October 23, 2014 4:48 pm | Comments

Environmental Tectonics Corporation announced October 23 the recent award of a new contract totaling in excess of $1 million for the Sterilization Systems Group.                


SmithGroupJJR adds Scott Kreitlein as Science & Technology Studio Leader

October 23, 2014 4:44 pm | Comments

SmithGroupJJR, one of the nation’s largest architecture, engineering, and planning firms, has hired Scott Kreitlein, AIA, LEED AP, as leader of the Science & Technology Studio at its Phoenix office. He joins SmithGroupJJR from HDR, Houston, where he was science & technology principal.


Walnuts May Reduce Risk of Alzheimer's

October 23, 2014 12:11 pm | Comments

A new animal study published in the Journal of Alzheimer’s Disease indicates that a diet including walnuts may have a beneficial effect in reducing the risk, delaying the onset, slowing the progression of, or preventing Alzheimer’s disease. 


Blind Cave Fish May Provide Insight on Eye Disease

October 23, 2014 11:46 am | Comments

Blind cave fish may not be the first thing that comes to mind when it comes to understanding human sight, but recent research indicates they may have quite a bit to teach us about the causes of many human ailments, including those that result in loss of sight. A team of researchers is looking to the tiny eyeless fish for clues about the underpinnings of degenerative eye disease and more.


David and Barbara Roux Provide $10 Million Gift For Genomic Medicine Research at JAX

October 23, 2014 11:27 am | The Jackson Laboratory | Comments

The Jackson Laboratory (JAX) has announced that technology investor David Roux and his wife Barbara have gifted $10 million to support research and find cures for genetically based diseases. The center will be based at the Laboratory’s locations in both Maine and Connecticut.


Drug Inhibits Tumor Growth in Mice

October 23, 2014 11:08 am | Comments

A new drug, known as OTS964, can eradicate aggressive human lung cancers transplanted into mice. The drug, given as a pill or by injection, inhibits the action of a protein that is overproduced by several tumor types, including lung and breast, but is rarely expressed in healthy adult tissues. Without this protein, cancer cells fail to complete the cell-division process and die.


Noise-Deafened Mice Hear Again

October 22, 2014 11:46 am | Comments

Scientists have restored hearing in noise-deafened mice, pointing way to new therapies for humans. The research team shows the key role of protein called NT3 in ear-to-brain communication. These findings pave the way for research in humans that could improve treatment of hearing loss caused by noise exposure and normal aging.


Focusing In on a Decades Old Mystery

October 21, 2014 11:41 am | Comments

Elvis did it, Michael Jackson did it, and so do the mitochondria in our cells. They shake. While Elvis and Michael shook for decades before loud and appreciative audiences, mitochondrial oscillations have quietly bewildered scientists for more than 40 years. Now, an NIH team has imaged mitochondria for the first time oscillating in a live animal - in this case, the salivary glands of laboratory rats.


Huntington's Study Halted Due to Rat Results

October 21, 2014 11:27 am | Comments

A biopharmaceutical company has suspended its Huntington's disease clinical trial as it further evaluates an observation from a nonclinical study in rats. Non-human primates exposed to plasma concentrations equal to those in the rat demonstrated no findings similar to the observation reported from the rat study.


Antibiotics May Increase Spread of Salmonella

October 21, 2014 11:13 am | by Bruce Goldman, Stanford University School of Medicine | Comments

Salmonella-infected mice that were given antibiotics became sicker and began shedding far more bacteria in their feces than they had before. But some “superspreader” mice remained healthy, unaffected by either the disease or the antibiotic. The study poses ominous questions about the widespread, routine use of sub-therapeutic doses of antibiotics in livestock.


Medical Imaging Detects Early Cancer in Lab Mice

October 21, 2014 10:15 am | Comments

A new medical imaging method could help physicians detect cancer and other diseases earlier than before, speeding treatment and reducing the need for invasive, time-consuming biopsies. The potentially lifesaving technique uses nanotechnology to reveal small cancerous tumors and cardiovascular lesions deep inside the body. The researchers have demonstrated positive results in laboratory mice.


Rat Study Helps to Understand Epilepsy, Other Brain Disorders

October 21, 2014 12:00 am | Comments

Researchers have used graphene, a two-dimensional form of carbon only one atom thick, to fabricate a new type of microelectrode that solves a major problem for investigators looking to understand the intricate circuitry of the brain. The team performed calcium imaging of hippocampal slices in a rat model with both confocal and two-photon microscopy, while also conducting electrophysiological recordings.



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