Looking across evolutionary time and the genomic landscapes of humans and mice, an international group of researchers has found powerful clues to why certain processes and systems in the mouse are so different from those in people. Building on years studies, they have developed a resource that can help scientists better understand how similarities and differences between mice and humans are written in their genomes.
A new study in mice shows that our natural gut-residing microbes can influence the integrity of...
Chemists have developed new nanoparticles that can simultaneously perform magnetic resonance...
Researchers have found that a growth factor can regenerate damaged peripheral nerves without causing the growth of new blood vessels — making it a unique candidate to treat nerve damage in areas of the body where the proliferation of blood vessels would be a drawback.
By manipulating the circadian clocks of Siberian hamsters, scientists may have identified a brain structure that disrupts memory when circadian rhythms fall apart, as they often do in patients with neurodegenerative diseases such as Alzheimer's.
It all started in 2008 at the University of North Carolina (UNC) School of Medicine. The goal: attract top investigators -- Ph.D.s, Ph.D. candidates, professors, and post grads — and fundamentally advance knowledge of cancer and other complex diseases. This is not a classroom building; it is a research facility.
Researchers have discovered how a previously unknown hormone serves as a messenger from fat cells to the liver and are investigating the potential of developing a new treatment for metabolic disorders.
Scientists have identified a novel delivery platform by which an antisense molecule — akin to the mirror image of the microRNA — can be used to exploit a unique feature of the tumor microenvironment and thereby gain access to cancer cells.
A team of scientists have found that a particular set of cells in a small region of the brain are responsible for memory problems after sleep loss. By selectively increasing levels of a signaling molecule in these cells, the researchers prevented mice from having memory deficits.
Scientists from Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) in Japan have developed an advanced imaging system to identify cells responsible for storing memory within a tiny worm. Their study not only offers a new way to identify molecular substrates of memory but may also one day lead to understanding how memory loss occurs in humans.
A team of researchers from Johns Hopkins Medicine has discovered a receptor on blood vessels that causes the vessel to relax in response to light, making it potentially useful in treating vascular diseases. In addition, researchers discovered a previously unknown mechanism by which blood vessel function is regulated through light of a specific wavelength.
Researchers have developed new insight into a rare but deadly brain infection, called progressive multifocal leukoencephalopathy. This disease – which is caused by the JC virus – is most frequently found in people with suppressed immune systems and, until now, scientists have had no effective way to study it or test new treatments.
In a presentation prepared for the Society for Neuroscience annual meeting in Washington, D.C., researchers say their experimental results, conducted in female mice, suggest how diets with fewer calories derived from carbohydrates likely deter some aspects of aging and chronic diseases in mammals, including humans.
Long-term exposure to triclosan, an antimicrobial agent commonly found in a broad array of soaps, shampoos, toothpastes and other consumer products, may have potentially serious health consequences. Data from a new study shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant for humans.
The brain’s ability to use energy is critical after an injury. In animal studies, Ohio State University scientists have shown that brain cells ramp up their energy use six days after a concussion to recover from the damage. If a second injury occurs before that surge of energy use starts, the brain loses its best chance to recover.
The Malt1 protein is one of the most important control centers in human immune cells and a real all-rounder. Genetic defects in it can lead to the development of lymphatic cancer. A possible therapeutic approach is therefore to specifically block certain functions of Malt1, thus destroying the cancer cells. Now, however, scientists have shown in a mouse model that such a blockade can cause serious side effects.
What do a mouse, a fly, a zebrafish, a worm, and yeast have in common? Together these five organisms hold the keys for scientists to better understand the basic molecular function of genes and specific gene mutations. The Canadian Institutes of Health Research has awarded the Canadian Rare Diseases Models and Mechanisms Network $2.3 million to investigate these molecular mechanisms and advance rare disease research.