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The Lead

Essential Protein Needed for Fertilization

April 17, 2014 | by Wellcome Trust Sanger Institute | Comments

Researchers have discovered interacting proteins on the surface of the sperm and the egg essential to begin mammalian life. These proteins, which allow the sperm and egg to recognize one another, offer new paths towards improved fertility treatments and the development of new contraceptives.



Cancer Drugs Block Dementia-linked Brain Inflammation in Mice

April 17, 2014 1:11 pm | by Univ. of California, Irvine | Comments

A class of drugs developed to treat immune-related conditions and cancer — including one currently in clinical trials for glioblastoma and other tumors — eliminates neural inflammation associated with dementia-linked diseases and brain injuries.


Cause of Eye Mobility Disorder Developed in Mouse Models

April 17, 2014 1:03 pm | by Steve Kehoe, Univ. of Iowa | Comments

Researchers have developed a mutated mouse model that mimics the human mutation of an eye mobility disorder in order to understand why it occurs.                             


Technique Reverse-engineers Developing Lung

April 16, 2014 1:08 pm | by Tom Abate, Stanford Univ. | Comments

In a feat of reverse tissue engineering, researchers have begun to unravel the complex genetic coding that allows embryonic cells to proliferate and transform into all of the specialized cells that perform a myriad of different biological tasks.  


Hair from Infant Monkeys Gives Clues about Life in the Womb

April 16, 2014 12:36 pm | by Kelly April Tyrrell, Univ. of Wisconsin-Madison | Comments

A team researchers show in a study of rhesus monkeys that hair can reveal the womb environment in which an infant formed.                                     


Mouse Model Would Have Predicted Toxicity of Fatal Drug

April 16, 2014 12:22 pm | by PLOS | Comments

Over 20 years after the fatal fialuridine trial, a study demonstrates that mice with humanized livers recapitulate the drug's toxicity.                                 


Why Does Eating Less Increase Life Span?

April 16, 2014 12:05 pm | by Annie Sneed, Scientific American | Comments

Nematode worms, fruit flies, mice and other lab animals live longer, healthier lives when they eat less than they otherwise would if more food were available. Researchers have declared the most popular theory doesn’t make evolutionary sense, and they’ve proposed a new explanation in its place.

'3D' Model Could Reduce Animal Testing of Asthma and Allergy Medications

April 16, 2014 9:40 am | by American Chemical Society | Comments

Scientists report that they’ve developed a simple, “3D” laboratory method to test asthma and allergy medications that mimics what happens in the body, which could help reduce the need for animal testing.             

Researchers Transplant Regenerated Esophagus in Rats

April 15, 2014 2:09 pm | by Karolinska Institutet | Comments

Tissue engineering has been used to construct natural esophagi, which in combination with bone marrow stem cells have been safely and effectively transplanted in rats.                        


Reversing Alzheimer's Symptoms in Mice

April 15, 2014 1:55 pm | by Deborah Halber, MIT | Comments

Limiting a certain protein in the brain reverses Alzheimer’s symptoms in mice. Researchers found that the overproduction of the protein known as p25 may be the culprit behind the sticky protein-fragment clusters that build up in the brains of Alzheimer's patients.


Age Matters for Regenerating Muscle in Duchenne MS Models

April 15, 2014 1:29 pm | by Susan Gammon, Sanford-Burnham Medical Research Institute | Comments

A team of scientists have published details of how a class of drugs called “HDACis” drive muscle-cell regeneration in the early stages of dystrophic muscles, but fail to work in late stages.                 


Finding Where Memory Begins

April 15, 2014 1:04 pm | by Latarsha Gatlin, Johns Hopkins Univ. | Comments

By tracking brain activity when an animal stops to look around its environment, neuroscientists believe they can mark the birth of a memory.                               


Register for the 2014 TurnKey Conference and Enter to Win a $1,000 Travel Voucher

April 15, 2014 10:55 am | Comments

One lucky attendee at this year’s TurnKey Conference will receive a $1,000 travel voucher to TurnKey 2015 to be held in San Diego!  The drawing will be held and the winner announced during the 2014 Conference, held May 13-14 at the Gaylord National Hotel in MD.  Winner must be present to win. 


Kenneth B Macleod August 23rd 1952 – March 26th 2014

April 14, 2014 4:19 pm | Comments

It is with great sorrow that ALN marks the passing of Ken Macleod. Ken leaves to mourn his wife Meg and their children. He will be sadly missed but never forgotten by his many friends and business associates.         

Stress Damage Blocked in Mice

April 14, 2014 2:08 pm | by Bill Hathaway, Yale Univ. | Comments

Ketamine, an anesthetic sometimes abused as a street drug, increases the synaptic connections between brain cells and in low doses acts as a powerful antidepressant. However, stress has the opposite effect, shrinking the number of synaptic spines, triggering depression.


Kidney Regeneration Linked to Gene Found in Mice

April 14, 2014 1:50 pm | by Boston Children's Hospital | Comments

Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise for children with Wilms.     



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