New findings show that the absence of a father during critical growth periods leads to impaired social and behavioral abilities in adults. Mice raised without a father had abnormal social interactions and were more aggressive than counterparts raised with both parents. These effects were stronger for female offspring than for their brothers.
It is well known that teenagers take risks — and when they do, they like to have company. Now, a...
Using the co-occurrence of brain and gut problems in Autism spectrum disorder (ASD) as their...
Life presents us with choices all the time. How we make these everyday decisions has been a topic of great interest to economists, who have devised theories about how we assign values to our options and use those values to make decisions. An emerging field of study known as neuroeconomics is combining the economists’ insights with scientific study of the brain to learn more about decision-making processes and how they can go awry.
A study points out that mice lacking a protein called Tmprss2 are no longer affected by certain flu viruses. It is likely that there are humans having the same defect as the mice and who therefore may be resistant against specific flu viruses. This, however, remains unnoticed.
Researchers at the Univ. of East Anglia (UEA) are launching a new project to develop methods which could one-day decrease the use of rats and mice in pharmaceutical testing. Researchers will use mammallian cells, early frog embryos and computer modelling in a bid to create a new way of predicting drug toxicity. It is hoped that this new model would reduce the need for animal testing in medical research.
Newborn mouse pups experience permanent brain changes when repeatedly overstimulated. Researchers stimulated young mice pups by excessively touching the pups' whiskers, prolonging treadmill sessions or playing chronic noise. When stimulated in one of these ways for five days or longer, the mice's brains had smaller, less-branched blood vessels.
A research team reports that the brain can produce and release estrogen — a discovery that may lead to a better understanding of hormonal changes observed from before birth throughout the entire aging process. The new research shows that the hypothalamus can directly control reproductive function in rhesus monkeys and very likely performs the same action in women.
In a seemingly simple experiment, a scientist exposes rats to a certain pesticide over several days, and the rodents start showing symptoms remarkably similar to those seen in Parkinson’s patients. But the scientific search for the causes of the disease, which affects 7 million to 10 million people worldwide, is nowhere near simple.
A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study. This discovery could help provide clues to the cause of some kinds of neonatal growth defects and may also help advance the development of stem cell models of disease.
A team of researchers has discovered that the protein PC7 plays a critical role in the brain by affecting certain types of cognitive performance such as anxiety, learning and emotional memory. Their results could have a significant impact on regulating behavior related to anxiety disorders and trauma.
In a groundbreaking study, neuroscientists discovered that prenatal exposure to alcohol significantly altered the expression of genes and the development of a network of connections in the neocortex — the part of the brain responsible for high-level thought and cognition, vision, hearing, touch, balance, motor skills, language, and emotion — in a mouse model of Fetal Alcohol Spectrum Disorders (FASD).
A successful joint collaboration may lead to a potential treatment of brain diseases. The researchers found that a novel and unique compound selectively inhibits the process of aging in order to protect the brain from neurodegenerative diseases, without affecting lifespan. This is a first and important step towards the development of future drugs for the treatment of various neurodegenerative maladies.
A pharmacological inhibitor, ATN-224, induced cancer cell death and reduced tumor sizes in a mouse model of lung adenocarcinoma. ATN-224 dependent effects in animals were improved when the inhibitor was used in combination with another drug that activates programmed cell death.
Scientists have identified an enzyme that can halt or possibly even reverse the build-up of toxic protein fragments known as plaques in the brains of mice with Alzheimer’s disease.
A new male contraceptive could be on the horizon after scientists identified a novel way to block the transport of sperm during ejaculation. Scientists have found that complete male infertility could be achieved by blocking two proteins found on the smooth muscle cells that trigger the transport of sperm.
A study suggests that a diet low in vitamin D causes damage to the brain. Middle-aged rats fed a diet low in vitamin D for several months developed free radical damage to the brain, and many different brain proteins were damaged as identified by redox proteomics. These rats also showed a significant decrease in cognitive performance on tests of learning and memory.
Even if the obesity trend cannot be reversed, here's hope that it's partner in crime — diabetes — might be thwarted. Research shows how a recently discovered human peptide, called humanin, could lead to powerful new treatments for some people living with diabetes. In mice and rats, humanin analogue (a peptide molecularly similar to humanin) increases insulin secretion leading to an increase in glucose metabolism within beta cells.