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The ability to pop a working copy of a faulty gene into a patient’s genome is a tantalizing goal for many clinicians treating genetic diseases. Now, researchers have devised a new way to carry out this genetic sleight of hand.

New Genome Editing Method Could Cure Hemophilia in Mice

October 30, 2014 | Comments

The ability to pop a working copy of a faulty gene into a patient’s genome is a tantalizing goal for many clinicians treating genetic diseases. Now, researchers have devised a new way to carry out this genetic sleight of hand.       

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Over the past decade, China has poured money into research, especially in the biomedical sciences. But as the nation’s health-care costs have risen in the past few years, critics have argued that the investment has not paid off. A group of researchers and

China Opens Translational Medicine Center in Shanghai

October 30, 2014 2:14 pm | by David Cyranoski, Nature | Comments

Over the past decade, China has poured money into research, especially in the biomedical sciences. But as the nation’s health-care costs have risen in the past few years, critics have argued that the investment has not paid off. A group of researchers and government officials now hopes to improve those returns with the official opening of the National Centre for Translational Medicine in Shanghai.

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Scientists used pluripotent stem cells to generate functional, three-dimensional human stomach tissue in a laboratory – creating an unprecedented tool for researching the development and diseases of an organ central to several public health crises, rangin

Mini-Stomachs Generated in Lab with Stem Cells

October 30, 2014 1:44 pm | by Cincinnati Children’s Hospital Medical Center | Comments

Scientists used pluripotent stem cells to generate functional, three-dimensional human stomach tissue in a laboratory — creating an unprecedented tool for researching the development and diseases of an organ central to several public health crises, ranging from cancer to diabetes.

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Glioma is a common name for serious brain tumors. Different types of glioma are usually diagnosed as separate diseases and have been considered to arise from different cell types in the brain. Now researchers have shown that one and the same cell of origi

Different Brain Tumors Have Same Origin

October 29, 2014 1:49 pm | by Linda Koffmar, Upsalla Univ. | Comments

Glioma is a common name for serious brain tumors. Different types of glioma are usually diagnosed as separate diseases and have been considered to arise from different cell types in the brain. Now researchers have shown that one and the same cell of origin can give rise to different types of glioma.

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Heavy drinking during adolescence may lead to structural changes in the brain and memory deficits that persist into adulthood, according to an animal study.

Heavy Drinking Produces Lasting Brain Changes, Memory Deficits in Adolescent Rats

October 29, 2014 1:39 pm | by Society for Neuroscience | Comments

Heavy drinking during adolescence may lead to structural changes in the brain and memory deficits that persist into adulthood, according to an animal study.                           

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Scientists have uncovered a major contributor to Huntington’s disease, a devastating progressive neurological condition that produces involuntary movements, emotional disturbance and cognitive impairment.

Major Factor in Development of Huntington's Disease Uncovered in Mice

October 29, 2014 1:22 pm | by The Scripps Research Institute | Comments

Scientists have uncovered a major contributor to Huntington’s disease, a devastating progressive neurological condition that produces involuntary movements, emotional disturbance and cognitive impairment.             

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A new effort mapping 24-hr patterns of expression for thousands of genes in 12 different mouse organs – five years in the making – provides important clues about how the role of timing may influence the way drugs work in the body.

Mouse Genome Shows Timing Efficacious for Drug Delivery

October 29, 2014 8:43 am | by Penn Medicine | Comments

A new effort mapping 24-hr patterns of expression for thousands of genes in 12 different mouse organs — five years in the making — provides important clues about how the role of timing may influence the way drugs work in the body.

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Researchers studied lipoproteins in Drosophila melanogaster and found that that the blood brain barrier is a main sensor to report the nutritional status, especially the lipid composition of consumed food to special neurons which in turn regulate Insulin

Lipids, Not Calories, Trigger Strong Insulin Response

October 28, 2014 3:46 pm | by Max Planck Society | Comments

Researchers studied lipoproteins in Drosophila melanogaster and found that that the blood brain barrier is a main sensor to report the nutritional status, especially the lipid composition of consumed food to special neurons which in turn regulate Insulin release. Calories play a rather minor role in this process.

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A study has revealed the underlying genetic factors that help repair skin lesions caused by psoriasis, which could engender new methods of controlling the lingering condition.

Healing Mechanism Identified in Mice with Psoriasis Lesions

October 28, 2014 3:04 pm | by UCLA | Comments

A study has revealed the underlying genetic factors that help repair skin lesions caused by psoriasis, which could engender new methods of controlling the lingering condition.                     

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Difficulty in conceiving a child is a major challenge for one in seven heterosexual couples in America, especially for those over the age of 35. Now a new discovery could boost the chances of conception in women undergoing in vitro fertilization (IVF) tre

Trying to Slow Biological Clock in Mice

October 28, 2014 2:49 pm | by American Friends of Tel Aviv Univ. | Comments

Difficulty in conceiving a child is a major challenge for one in seven heterosexual couples in America, especially for those over the age of 35. Now a new discovery could boost the chances of conception in women undergoing in vitro fertilization (IVF) treatments.

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Do blood vessels that feed tumors differ from other blood vessels? Fourteen   years ago, experiments designed to answer that question led to the discovery   of several genes that are more active in tumor-associated blood vessels than   in normal blood ves

Tumor Blood Vessels Share Gene with Brain Blood Vessels

October 28, 2014 2:37 pm | by Johns Hopkins Medicine | Comments

Do blood vessels that feed tumors differ from other blood vessels? Fourteen years ago, experiments designed to answer that question led to the discovery of several genes that are more active in tumor-associated blood vessels than in normal blood vessels. Research now reveals the normal function of one of those genes and suggests it could be a good target for anticancer drug therapy.

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In an effort to reduce sex bias in biomedical studies, the NIH announced in May a new policy that will roll out practices promoting sex parity in research. But at a broad level, it might make sense to study only males when examining biological processes.

Is NIH policy the best way to sex equality in studies?

October 27, 2014 3:44 pm | by Bethany Brookshire, Science News | Comments

In an effort to reduce sex bias in biomedical studies, the NIH announced in May a new policy that will roll out practices promoting sex parity in research. But at a broad level, it might make sense to study only males when examining biological processes.

A report by Chinese researchers in the journal Nature a few months ago was a small sensation: they appeared to have found the cause for why organisms age. An international team of scientists has now refuted a basic assumption of that article. The reasons

Mitochondria Connection to Aging Remains Elusive

October 27, 2014 3:28 pm | by Univ. of Bonn | Comments

A report by Chinese researchers in the journal Nature a few months ago was a small sensation: they appeared to have found the cause for why organisms age. An international team of scientists has now refuted a basic assumption of that article. The reasons for aging thus remain elusive.

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A study reveals that a fractured arm bone in newborn mice can rapidly realign through a previously unknown mechanism involving bone growth and muscle contraction.

How Newborn Mice Repair Bone Fractures Could Improve Treatments

October 27, 2014 3:14 pm | by Cell Press | Comments

A study reveals that a fractured arm bone in newborn mice can rapidly realign through a previously unknown mechanism involving bone growth and muscle contraction.                         

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Digoxin, a medication used in the treatment of heart failure, may be adaptable for the treatment of amyotrophic lateral sclerosis (ALS), a progressive, paralyzing disease, suggests new mouse research.

Heart Drug Treats ALS in Mice

October 27, 2014 2:50 pm | by Michael Purdy, Washington Univ. | Comments

Digoxin, a medication used in the treatment of heart failure, may be adaptable for the treatment of amyotrophic lateral sclerosis (ALS), a progressive, paralyzing disease, suggests new mouse research.              

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Lambs Advance Treatment for Respiratory Syncytial Virus in Infants

October 24, 2014 10:05 am | Comments

Veterinary research involving lambs at Iowa State University is helping to advance new treatments to a common virus in humans that sometimes poses a serious threat to newborns.             

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