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The Lead

Carnival Night Charity Gala Benefits Homes for Animal Heroes

September 29, 2015 | by Elizabeth Doughman, Editor-in-Chief | Comments

Topaz Technologies is proud to announce a free Carnival Night Charity Gala for Thursday, November 5, from 3-8 PM at On Jackson, in Phoenix, AZ. The Gala will benefit Homes for Animal Heroes, the first and only nationwide research friendly animal rehoming network.



Decoding What Goes Wrong in Arthritis

October 8, 2015 11:22 am | Comments

Scientists have discovered what they believe has the potential to prevent the onset of an aggressive and hard-to-treat form of rheumatoid arthritis. In a new study, a team of immunologists describe how an immune system protein - interleukin-27 - regulates the inflammatory process in lymphoid-rich rheumatoid arthritis, which causes the characteristic symptoms of swollen and painful joints.


NIH Scientists Identify How Normally Protective Immune Responses Kill Neurons

October 8, 2015 11:12 am | Comments

Many brain disorders involve the death of neurons, or nerve cells, but how these neurons die is not well understood. A new study in The Journal of Immunology describes how the activation of normally protective immune responses causes nerve cells to die and identifies the protein responsible, providing a potential target for therapeutic intervention.


Extremely Active Rats Become Lazy When They Artificially Receive "Runners High"

October 8, 2015 11:04 am | Comments

Past research has shown that the pleasure and reward centers of the brain are activated similarly by dangerous drugs as well as by exercise, which is why therapies have been developed for drug addicts that include lots of exercise. Now, researchers have found that activating these pleasure and reward receptors in the brain could provide the “reward” of dangerous drugs without having to consume those drugs.


Just How Effective is the Mouse Grimace Scale?

October 8, 2015 9:49 am | by Elizabeth Doughman, Editor-in-Chief | Comments

The Mouse Grimace Scale needs further research before it can be considered an effective tool for routine pain assessment in laboratory animals, according to recent study in PLOS One. The study found that baseline (non-painful) scores varied significantly between the some strains and sexes of laboratory mice, indicating that consistency is potentially dependent on having baseline scores for any animal being assessed for pain.


Horse Illness Shares Signs of Human Disease

October 7, 2015 11:04 am | Comments

Horses with a rare nerve condition have similar signs of disease as people with conditions such as Alzheimer’s, a study has found.


Finches Offer Researchers a New Tool to Study Huntington's Disease

October 7, 2015 10:57 am | Comments

Many neurological disorders can rob someone of the ability to speak clearly, causing them to stutter, mispronounce words, and struggle to put together coherent sentences. Recent work may give researchers a new tool to better study these vocal and speech impairments, particularly in Huntington’s disease.


Scientists Test New Gene Therapy for Vision Loss from a Mitochondrial Disease

October 7, 2015 10:39 am | Comments

Researchers funded by the National Institutes of Health have developed a novel mouse model for the vision disorder Leber hereditary optic neuropathy (LHON), and found that they can use gene therapy to improve visual function in the mice. LHON is one of many diseases tied to gene mutations that damage the tiny energy factories that power our cells, called mitochondria.


Nanoparticulate Carbon Black Particles are the Tiny Culprits that Start Emphysema

October 7, 2015 10:17 am | Comments

When pathologists perform autopsies on smokers who died with severe emphysema, they find that lungs are black in appearance. Until recently, researchers and physicians could only guess at the composition of the material that gave the black color to the lungs of smokers.


Gut Development During Mouse Infancy Key to Lifelong Health

October 7, 2015 9:22 am | by Elizabeth Doughman, Editor-in-Chief | Comments

The suckling period in mice is crucial for the development of gut health, according to a new study published in the journal, Genome Biology. This time period is critical because of the number of epigenetic changes that occur during the development of stem cells in the intestine.  


High-fructose Diet Hampers Recovery from Traumatic Brain Injury

October 6, 2015 11:17 am | by Elaine Schmidt, UCLA | Comments

A diet high in processed fructose sabotages rats’ brains’ ability to heal after head trauma, UCLA neuroscientists report.


Scientists Closer to Controlling Body Temperature in Response to 'Fight or Flight'

October 6, 2015 10:23 am | Comments

New research published online in The FASEB Journal suggests that the fight or flight response that we experience in stressful situations may be controlled by a protein called TRPV1. In the mouse study, researchers found that TRPV1 controls the nerves that release noradrenaline and affect core body temperature. This opens the doors for the development of new strategies to treat the effects of stress on the body.


Drug Used to Treat Cancer Appears to Sharpen Memory

October 6, 2015 9:57 am | by Robin Lally, Rutgers University | Comments

Can you imagine a drug that would make it easier to learn a language, sharpen your memory and help those with dementia and Alzheimer’s disease by rewiring the brain and keeping neurons alive?


Nerve Cells Sing One of Two Tunes in Zebrafish Brains

October 6, 2015 9:01 am | by Elizabeth Doughman, Editor-in-Chief | Comments

Nerve cells located at the base of zebrafish brains send out electrical signals to two "tunes," either in sudden bursts and at a constant hum, according to a new study from the National Centre for Biological Sciences in India. This discovery could lead to new therapies for autism, ataxia, alcoholism, and more.


Can Exercise Be Replaced with a Pill?

October 5, 2015 10:04 am | Comments

Everyone knows that exercise improves health, and ongoing research continues to uncover increasingly detailed information on its benefits for metabolism, circulation, and improved functioning of organs such as the heart, brain, and liver. With this knowledge in hand, scientists may be better equipped to develop "exercise pills" that could mimic at least some of the beneficial effects of physical exercise on the body.


Nobel Prize for Medicine Shared by Three Scientists for Work on Parasitic Diseases

October 5, 2015 9:48 am | by Seth Augenstein, Digital Reporter | Comments

William C. Campbell and Satoshi Omura developed a drug called Avermectin which has successfully beaten back River Blindness and Lymphatic Filariasis, along with other diseases caused by parasites. Youyou Tu discovered another drug called Artemisinin which significantly reduced death rates from malaria.



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