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The Lead

Study IDs New Targets for Reducing Nerve Pain

March 2, 2016 | by Hiroshima University | Comments

A specific molecule involved in maintaining pain after a nerve injury has been identified and blocked in mice by Hiroshima University researchers. These results reveal a promising therapeutic strategy for treating neuropathic pain.


Immune Cells Can Heal Muscle, Mouse Study Says

May 3, 2016 3:12 pm | by Elizabeth Doughman, Editor-in-Chief | Comments

Immune system cells direct healing of mouse muscle wounds when paired with biological 'scaffolding,' according to a new study from researchers at Johns Hopkins University. This finding indicates that the immune system does more than just fighting infections and other diseases; it also helps the healing process begin after an injury.


Advance Could Help Grow Stem Cells More Safely

May 3, 2016 9:54 am | by David Orenstein, Brown University | Comments

The most productive way scientists have devised to nurture colonies of human embryonic stem cells is to do so atop a bed of mouse cells. That may be fine for lab research, but it poses an unacceptable contamination risk for stem cells intended for transplant into human patients.


New Drug Delivery Approach Holds Potential for Treating Obesity

May 3, 2016 9:45 am | by Anne Trafton, MIT | Comments

Researchers at MIT and Brigham and Women’s Hospital have developed nanoparticles that can deliver antiobesity drugs directly to fat tissue. Overweight mice treated with these nanoparticles lost 10 percent of their body weight over 25 days, without showing any negative side effects.


New Cancer Drugs Could Treat Lethal Resistant Prostate Cancers

May 3, 2016 9:18 am | Comments

Men with aggressive prostate cancer that has stopped responding to conventional treatment could potentially benefit from a new class of cancer drug designed to overcome drug resistance, a new study suggests.


Radiation and Immunotherapy Combination Can Destroy Both Primary and Secondary Tumors

May 3, 2016 9:18 am | Comments

Research presented at the ESTRO 35 conference shows that the addition of an immune system-strengthening compound can extend the radiation therapy-induced immune response against the tumor sites and that this response even has an effect on tumors outside the radiation field.


Possible Substitute for Antibiotics to Treat Dangerous Infections Identified

May 3, 2016 9:17 am | Comments

A recently published paper identifies a new therapeutic target for the treatment of bacterial infections that regulates the immune response. Researchers at Lund University have now found an "off" switch for destructive inflammation in infected kidneys that does not impair the anti-bacterial defense


Gene Therapy Halts Progression of Pulmonary Hypertension in Pigs

May 2, 2016 10:36 am | Comments

Scientists have used a novel gene therapy to halt the progression of pulmonary hypertension, a form of high blood pressure in the lung blood vessels that is linked to heart failure, according to a new study.


Scientists Turn Skin Cells Into Heart Cells and Brain Cells Using Drugs

May 2, 2016 10:12 am | by Dana G. Smith, Ph.D., Gladstone Institutes | Comments

In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals. All previous work on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat.


Study Shows How Neurons Decline as Parkinson's Develops

May 2, 2016 10:04 am | by Will Sansom, University of Texas Health Science Center at San Antonio | Comments

It's an unsettling thought: You could be walking around for 20 years developing Parkinson's disease and not even know it. And once symptoms appear, it's too late for a cure. What if a therapy that treats the root causes of Parkinson's, not just the symptoms, could be started earlier?


Size of Tumor May Affect Whether Cells Can Metastasize

May 2, 2016 9:39 am | by Liz Ahlberg, University of Illinois at Urbana-Champaign | Comments

Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new University of Illinois study.


"Fireflies" Light the Way to Understanding Female HIV Transmission

April 29, 2016 9:55 am | by Marla Paul, Northwestern University | Comments

Finding the vulnerable points where HIV enters the female reproductive tract is like searching for needles in a haystack. But Northwestern Medicine scientists have solved that challenge by creating a glowing map of the very first cells to be infected with a HIV-like virus.


Probiotics Stop Menopause-like Bone Loss in Mice

April 29, 2016 9:45 am | Comments

Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers at Emory University School of Medicine and Georgia State University have shown.


Nanoparticles Hold Promise As Double-edged Sword Against Genital Herpes

April 29, 2016 9:36 am | by Sharon Parmet, University of Illinois at Chicago | Comments

An effective vaccine against the virus that causes genital herpes has evaded researchers for decades. But now, researchers from the University of Illinois at Chicago working with scientists from Germany have shown that zinc-oxide nanoparticles shaped like jacks can prevent the virus from entering cells, and help natural immunity to develop.


Analysis of Dog Genome Will Provide Insight Into Human Disease

April 29, 2016 9:32 am | Comments

An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies -- according to a new study led by The Genome Analysis Centre (TGAC).


Serotonin Could Be Clue to Understanding SIDS

April 29, 2016 9:26 am | Comments

Although safe sleeping environments and reduction of behaviours associated with an increased risk of SIDS have reduced the number of events, SIDS and Asphyxia (lack of oxygen) remain among the most common causes of death in infants between the age of one month and one year.



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