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The Lead

Targeting Immunosuppression in Brain Tumors

January 11, 2016 | by Nora Dunne, Northwestern University | Comments

The standard of care for adult patients with glioblastoma includes surgical resection, radiotherapy and chemotherapy, but even with those aggressive treatments median survival is only just over a year. The goal of the researchers is to understand how manipulating immunosuppressive pathways can increase survival when combined with existing therapies.


Brain Formation Patterns in Mice Suggest How Trauma May Cause Disease But Leave No Clues

February 5, 2016 10:03 am | Comments

Some of the earliest nerve cells to develop in the womb shape brain circuits that process sights and sounds, but then give way to mature networks that convert this sensory information into thoughts.


Investigating How Antidepressant Exposure Affects the Developing Fetus

February 5, 2016 10:02 am | Comments

Depression is a serious issue for expecting mothers. Left untreated, depression could have implications for a fetus's health. But treating the disease during pregnancy may carry health risks for the developing fetus, which makes an expecting mother's decision whether to take medication a very difficult one.


Receptors Inside Nerve Cells May Be a Key to Controlling Pain

February 5, 2016 10:02 am | by Jim Dryden, Washington University School of Medicine | Comments

In real estate, location is key. It now seems the same concept holds true when it comes to stopping pain.


Nutrient Deprivation Kills Kidney Cancer Cells

February 5, 2016 10:01 am | by Marla Vacek Broadfoot, Duke University | Comments

Duke University researchers have discovered a promising target for renal cell carcinomas. A study appearing online Feb. 1, 2016 in Cancer Research shows that the majority of these cancers rewire their metabolism in a way that leaves them addicted to an outside nutrient called cystine.


Potential New Approaches to Treating Eye Diseases

February 5, 2016 10:01 am | Comments

A team of researchers discovered that a pro-inflammatory signaling protein, or cytokine, called IL-33, plays a key role in recruiting phagocytes to damaged retina and inducing retinal degeneration.


Drug Prevents Key Age-Related Brain Change in Rats

February 4, 2016 9:57 am | Comments

As brain cells age they lose the fibers that receive neural impulses, a change that may underlie cognitive decline. Researchers at the University of California, Irvine recently found a way to reverse this process in rats.


Sharpen Emerges From the Pack as a Regulator of Inflammation

February 4, 2016 9:56 am | Comments

It is normal for our immune system to occasionally fly into an inflammatory rage to defend the host (us) against pathogens or even tumor cells. Problems arise when the rage persists or is re-directed against one’s self, as occurs in autoimmune disease.


What Can Ravens Tell Us About the Human Brain?

February 4, 2016 9:56 am | by Jeannie Kever, University of Houston | Comments

New research suggests that ravens share at least some of the human ability to think abstractly about other minds, adapting their behavior by attributing their own perceptions to others.


Researchers Discover a New Target for the Treatment of Fatty Liver Disease

February 4, 2016 9:55 am | Comments

Two proteins, p38 gamma and p38 delta, control the accumulation of fat in the liver, a process linked to the development of insulin resistance and diabetes, which are common outcomes of obesity. The study shows that inhibition of these proteins with specific inhibitors has potential as a treatment for fatty liver disease.


Mouse-Human Chimeras Allow Researchers to Discover Disease Development In Vivo

February 4, 2016 9:54 am | by Elizabeth Doughman, Editor-in-Chief | Comments

A new mouse-human modeling system could be used to study neural crest development as well as the modeling of a variety of diseases, according to a new study from the Whitehead Institute.


CRISPR/Cas9 Therapeutic for Tyrosinemia Type 1 Delivered in Mice

February 3, 2016 10:33 am | by Jim Fessenden, University of Massachusetts Medical School | Comments

University of Massachusetts Medical School researchers have found a way to more efficiently delivery a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I that may also prove to be safer for use in humans.


Researchers Develop a Better Model for Parkinson's

February 3, 2016 10:32 am | Comments

Scientists at EPFL have solved a longstanding problem with modeling Parkinson’s disease in animals. Using newfound insights, they have improved both cell and animal models for the disease, which can propel research and drug development.


Cancer Cells Travel Together to Forge 'Succesful' Metastases

February 3, 2016 10:27 am | Comments

There’s apparently safety in numbers, even for cancer cells. New research in mice suggests that cancer cells rarely form metastatic tumors on their own, preferring to travel in groups since collaboration seems to increase their collective chances of survival, according to researchers at Johns Hopkins.


With a Broken Circadian Clock, Even a Low-salt Diet Can Result in Heart Disease

February 3, 2016 10:25 am | by Toni Baker, Medical College of Georgia at Augusta University | Comments

In the face of a disrupted circadian rhythm, a low-salt diet and a hormone known to constrict blood vessels have the same unhealthy result: elevated resting blood pressure and vascular disease, scientists report.


Y Not? Mice That Lack Y Chromosome Able to Reproduce with Assistance

February 2, 2016 1:53 pm | by Elizabeth Doughman, Editor-in-Chief | Comments

Male mice without any Y chromosome genes can father offspring with assisted reproduction, according to a new study from the University of Hawaii at Monoa. This finding furthers understanding of the Y chromosome gene function and evolution.



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