A number of therapies are available to help drug users quit, but addiction is extremely tough to beat. Scientists are working on vaccines to neutralize the high-inducing effects of recreational drugs, like cocaine. A new study has hit upon an approach that might annul cocaine's additive buzz.
Tens of millions of people around the world have abnormal, leak-prone sproutings of blood...
A study shows that decreasing the number of A2A adenosine receptors in a particular type of...
Use of the same antiangiogenesis drugs that have improved treatment of some cancers could also...
ALN recently asked readers what kind of housing and housing equipment they use in your vivarium. Click here to see the results.
John J. Sabine, Jr. passed away on October 18, 2014, at 60 years of age. He was born in 1953 in Canandaigua NY. He was raised in Morristown, N.J. and lived in Mendham, N.J. for the past 20 years.
Resistance of leukemia cells to contemporary chemotherapy is one of the most formidable obstacles to treating acute lymphoblastic leukemia, the most common form of childhood cancer. Now researchers have designed and developed a new protein-based therapy they believe will prove highly effective against drug-resistant leukemia cells.
The Flexible Front Isolator Glove Box by Park Bioservices provides the highest level of biosecurity to the laboratory animal research community. It is also a solution for “germfree housing” of Gnotobiotic rodents.
Reducing the use of laboratory animals has been a long-term goal in biological research. Many in vivo assays, like rabbit endotoxin testing or mouse antibody production testing to detect viral contaminants have largely been replaced by in vitro enzyme or PCR-based assays.
This week's Tales From the Lab is Karl Arend, Project Manager at Art's Way Scientific from Decorah, Iowa. Art's Way Scientific designs, manufactures, and installs custom facilities for laboratory animal research, biocontainment, triage, public health, and general laboratory requirements.
Immune cells known as mast cells play a primary role in allergic reactions. Mast cells are activated by immunoglobulin E (IgE) antibodies and release inflammatory chemicals like histamine. Some compounds, however, can activate mast cells without interacting with IgE antibodies, triggering a so-called “pseudo-allergic” reaction. These substances, known as basic secretagogues, include many drugs that can cause allergic reactions.
New telemetry implants expected to change how large animal toxicology studies are conducted. Data Sciences International (DSI) has released a new series of digital telemetry implants to meet the changing needs of preclinical toxicology researchers. M series, part of the PhysioTel™ Digital platform, was designed to help toxicologists collect physiologic data when incorporating functional endpoints into repeat-dose toxicology studies.
Stress hormones in the mother can affect fetal development, according to a study published in The Journal of Physiology. Researchers found that increased levels of glucocorticoid stress hormones in pregnant mice caused the mother to eat more but reduced the ability of the placenta to transport glucose to her fetus.
Scientists have long known that sleep, memory, and learning are deeply connected. Most animals, from flies to humans, have trouble remembering when sleep deprived, and studies have shown that sleep is critical in converting short-term into long-term memory, a process known as memory consolidation. But just how that process works has remained a mystery.
ALS is notoriously difficult to treat, and relatively little is known about exactly how and why it occurs. In a rare discovery, a clear molecular defect has been found at the junctions between neurons and muscles, which may provide greater insight into the fundamental mechanisms of ALS, according to a new study.
The "storm of the century" is about to hit the eastern seaboard, from New Jersey to Maine. In some areas, 3+" of snow and hurricane-force winds are predicted. In a press conference yesterday, New York Mayor, Bill deBlasio warned that this "may be the worst snowstorm that New York has ever seen." ALN wants your facility to be prepared, so we're sharing this article on disaster planning from our archives.
A study has shown that a modified form of the superabsorbent chemical used in disposable diapers can expand brain structures to four and a half times their original size. The process called expansion microscopy will allow scientists to take super-resolution pictures of healthy and diseased tissue throughout the body using common microscopes.
Inflammation has long been studied in Alzheimer’s, but in a counterintuitive finding reported, researchers have uncovered the mechanism by which anti-inflammatory processes may trigger the disease.
Upending decades-old dogma, a team of scientists say enzymes long categorized as promoting cancer are, in fact, tumor suppressors and that current clinical efforts to develop inhibitor-based drugs should instead focus on restoring the enzymes’ activities.