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Look for the New ALN!

September 29, 2014 | by Elizabeth Doughman | News | Comments

Check your mailbox for the new ALN Magazine! With this redesign, we are now able to better serve you, our readers. One of the new things the October issue of ALN will feature is fresh, current content and columns.                     

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O.I.E. (World Organisation for Animal Health) regulations will require testing amphibians for disease prior to shipment. The two diseases of particular concern were Chytrid fungus and Ranaviruses. Nasco has chosen to be pro-active and has tested our frog

Xenopus Colony

September 29, 2014 4:53 pm | Nasco | Product Releases | Comments

O.I.E. (World Organisation for Animal Health) regulations will require testing amphibians for disease prior to shipment. The two diseases of particular concern were Chytrid fungus and Ranaviruses. Nasco has chosen to be pro-active and has tested our frog colony in advance of the mandated regulations.

A spice commonly found in curries may boost the brain's ability to heal itself. A German study suggests a compound found in turmeric could encourage the growth of nerve cells thought to be part of the brain's repair kit.

Tumeric Boosts Brain Repair in Rats

September 29, 2014 12:04 pm | by Smitha Mundasad, BBC | News | Comments

A spice commonly found in curries may boost the brain's ability to heal itself. A German study suggests a compound found in turmeric could encourage the growth of nerve cells thought to be part of the brain's repair kit.         

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A triple-punch of antibodies both prevented hepatitis C infection and wiped out the disease after it had established itself in laboratory mice. Instead of delivering the three antibodies directly, researchers administered a genetic "instruction set" that,

Genetic Antibody Instructions Knock Down Hepatitis C in Mice

September 29, 2014 11:02 am | by Princeton Univ. | News | Comments

A triple-punch of antibodies both prevented hepatitis C infection and wiped out the disease after it had established itself in laboratory mice. Instead of delivering the three antibodies directly, researchers administered a genetic "instruction set" that, once in a cell, developed into antibodies that target the portions of the virus that do not mutate.

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Coulbourn Instruments' Small Animal Treadmills are ideal for forced exercise training and muscle fatigue studies in rodents. Benefits include reduced stress to subjects and smooth operation with the high performance, silent motor, even at high speeds.

Small Animal Treadmill

September 29, 2014 8:30 am | Harvard Apparatus | Product Releases | Comments

Coulbourn Instruments' Small Animal Treadmills are ideal for forced exercise training and muscle fatigue studies in rodents. Benefits include reduced stress to subjects and smooth operation with the high performance, silent motor, even at high speeds.

Researchers have created a new mouse model to simplify application of the CRISPR-Cas9 system for in vivo genome editing experiments.

Researchers Engineer 'Cas9' Animal Models

September 26, 2014 12:14 pm | by Broad Institute | News | Comments

Researchers have created a new mouse model to simplify application of the CRISPR-Cas9 system for in vivo genome editing experiments.                                 

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Scientists have identified a protein in the human intestine that helps to protect against attack from opportunistic bacteria that strike when our defences are down. The protein receptor is activated during illness, producing a force field on the gut's sur

Protein Controls Gut's Protective Force Field in Mouse Models

September 26, 2014 11:52 am | by Wellcome Trust Sanger Institute | News | Comments

Scientists have identified a protein in the human intestine that helps to protect against attack from opportunistic bacteria that strike when our defences are down. The protein receptor is activated during illness, producing a force field on the gut's surface made of a sugary substance that encourages the growth of protective bacteria.

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Fall 2014 ALN World

September 26, 2014 11:48 am | Digital Editions | Comments

The Fall 2014 ALN World digital edition is here!

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A protein implicated in several cancers appears to play a pivotal role in keeping stem cells in an immature "pluripotent" state, according to a new study.

Scientists Identify Key Factor that Maintains Stem Cell Identity

September 26, 2014 11:31 am | by NYU Langone Medical Center | News | Comments

A protein implicated in several cancers appears to play a pivotal role in keeping stem cells in an immature "pluripotent" state, according to a new study.                           

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How do I determine what kind of bedding to use in my facility?

September 26, 2014 8:19 am | by Josh Faehner | Articles | Comments

Deciding what kind of animal bedding to use in your facility is an important but often overlooked consideration that plays a large role in the welfare of your animals. Bedding is one of the few items with which your animal is always in constant contact. The bedding you choose is where your animals will sleep, play, and spend the majority of their lives.

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Thoren’s Maxi Miser® IVC Caging Systems feature 9 mouse cages, 4 rat cages and 1 Guinea Pig cage. The interchangeable Maxi-Miser® Duplex Cages provide the ideal housing for pairing mice and breeding on the same rack with the standard size cages.

Interchangeable IVC Housing Systems

September 25, 2014 4:40 pm | Thoren Caging Systems, Inc. | Product Releases | Comments

Thoren’s Maxi Miser® IVC Caging Systems feature 9 mouse cages, 4 rat cages and 1 Guinea Pig cage. The interchangeable Maxi-Miser® Duplex Cages provide the ideal housing for pairing mice and breeding on the same rack with the standard size cages.  

A synthetic derivative of vitamin D was found by Salk Institute researchers to collapse the barrier of cells shielding pancreatic tumors, making this seemingly impenetrable cancer much more susceptible to therapeutic drugs.

Modified Vitamin D Treats Pancreatic Cancer in Mice

September 25, 2014 4:14 pm | by Salk Institute for Biological Studies | News | Comments

A synthetic derivative of vitamin D was found by Salk Institute researchers to collapse the barrier of cells shielding pancreatic tumors, making this seemingly impenetrable cancer much more susceptible to therapeutic drugs.       

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In a significant advance against the problem of cancer metastasis, scientists have shown that a specially developed compound can impede multiple myeloma from spreading to the bones in mice.

Novel Compound Prevents Metastasis of Multiple Myeloma in Mouse Studies

September 25, 2014 3:12 pm | by Dana-Farber Cancer Institute | News | Comments

In a significant advance against the problem of cancer metastasis, scientists have shown that a specially developed compound can impede multiple myeloma from spreading to the bones in mice.                 

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The traditional understanding in neuroscience is that tactile sensations from the skin are only assembled to form a complete experience in the cerebral cortex. However, this is challenged by new research that suggest both that other levels in the brain pl

How the Brain Handles Tactile Sensations

September 25, 2014 12:35 pm | by Lund Univ. | News | Comments

The traditional understanding in neuroscience is that tactile sensations from the skin are only assembled to form a complete experience in the cerebral cortex. However, this is challenged by new research that suggest both that other levels in the brain play a greater role than previously thought, and that a larger proportion of the brain’s different structures are involved in the perception of touch.

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Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of researchers has now hijacked that delivery system for a different purpose: administe

Chemists Recruit Anthrax to Deliver Cancer Drugs

September 25, 2014 12:19 pm | by Anne Trafton, MIT | News | Comments

Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of researchers has now hijacked that delivery system for a different purpose: administering cancer drugs.

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Researchers have found proof that Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, actually physically damages the heart. The bacterium leaves tiny lesions that researchers detected in mouse, rhesus macaque and human autopsy ti

Pneumonia Bacterium Leaves Tiny Lesions in the Heart

September 25, 2014 12:09 pm | by UT Health Science Center | News | Comments

The researchers have found proof that Streptococcus pneumoniae, the leading cause of community-acquired pneumonia, actually physically damages the heart. The bacterium leaves tiny lesions that researchers detected in mouse, rhesus macaque and human autopsy tissue samples.

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