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The New ALN Features Smaller Size and Updated Look

October 1, 2014 | by Elizabeth Doughman | News | Comments

Check your mailbox next week to see the new ALN Magazine! With this redesign, we are now able to better serve you, our readers. The October issue of ALN will feature a smaller size and updated design.                          

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Researchers have described a new approach to discovering potential cancer   treatments that requires a fraction of the time needed for more traditional   methods. They used the platform to identify a novel antibody that is   undergoing further investigati

Discovery Accelerates Identification of Potential Cancer Treatments

October 1, 2014 1:58 pm | by Univ. of Michigan | News | Comments

Researchers have described a new approach to discovering potential cancer treatments that requires a fraction of the time needed for more traditional methods. They used the platform to identify a novel antibody that is undergoing further investigation as a potential treatment for breast, ovarian and other cancers.

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Ongoing research is investigating the connection between initial seizures and the onset of epilepsy later in life.

Exploring New Possibilities for the Treatment of Epilepsy

October 1, 2014 1:41 pm | by Iowa State Univ. | News | Comments

Ongoing research is investigating the connection between initial seizures and the onset of epilepsy later in life.                                       

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The Zigg is designed for the biggest of chewers. It is one of the largest, solid thermoplastic toys available and is ideal for primates and dogs. The dimpled nubs on each end add an extra level of interest.

Thermoplastic Toys

October 1, 2014 8:21 am | Otto Environmental, LLC | Product Releases | Comments

The Zigg is designed for the biggest of chewers. It is one of the largest, solid thermoplastic toys available and is ideal for primates and dogs. The dimpled nubs on each end add an extra level of interest.

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Engineers have devised a way to rapidly test hundreds of different drug-  delivery vehicles in living animals, making it easier to discover promising   new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA, and

High-speed Drug Screen Devised for Testing in Zebrafish

September 30, 2014 1:03 pm | by Anne Trafton, MIT | News | Comments

Engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA, and DNA, to human patients.

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Scientists have discovered that a gene mutation linked to hereditary spastic   paraplegia, a disabling neurological disorder, interferes with the normal   breakdown of triglyceride fat molecules in the brain. The researchers found   large droplets of trig

Cause of Spastic Paraplegia Seen in Mice

September 30, 2014 12:47 pm | by The Scripps Research Institute | News | Comments

Scientists have discovered that a gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain. The researchers found large droplets of triglycerides within the neurons of mice modeling the disease.

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In the second of two papers outlining new gene-therapy approaches to treat a   rare disease called MPS I, examined systemic delivery of a vector to replace the enzyme IDUA, which is deficient in patients with this disorder.

Targeting Liver Corrects Symptoms in Feline Enzyme Disease Model

September 30, 2014 12:29 pm | by Penn Medicine | News | Comments

In the second of two papers outlining new gene-therapy approaches to treat a rare disease called MPS I, examined systemic delivery of a vector to replace the enzyme IDUA, which is deficient in patients with this disorder.        

The idea of mapping the brain is not new. Researchers have known for years that the key to treating, curing, and even preventing brain disorders is to understand how the brain records, processes, stores, and retrieves information. Now, new research makes

Single-Neuron 'Hub' Orchestrates Activity of Entire Brain Circuit in Mice

September 30, 2014 12:05 pm | by American Friends of Tel Aviv Univ. | News | Comments

The idea of mapping the brain is not new. Researchers have known for years that the key to treating, curing, and even preventing brain disorders is to understand how the brain records, processes, stores, and retrieves information. Now, new research makes a major contribution to efforts to navigate the brain.

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Researchers have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer’s disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition.

Cause of Frontotemporal Dementia also Implicated in Alzheimer's Disease

September 30, 2014 11:45 am | by Gladstone Institutes | News | Comments

Researchers have shown that low levels of the protein progranulin in the brain can increase the formation of amyloid-beta plaques (a hallmark of Alzheimer’s disease), cause neuroinflammation, and worsen memory deficits in a mouse model of this condition.

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O.I.E. (World Organisation for Animal Health) regulations will require testing amphibians for disease prior to shipment. The two diseases of particular concern were Chytrid fungus and Ranaviruses. Nasco has chosen to be pro-active and has tested our frog

Xenopus Colony

September 29, 2014 4:53 pm | Nasco | Product Releases | Comments

O.I.E. (World Organisation for Animal Health) regulations will require testing amphibians for disease prior to shipment. The two diseases of particular concern were Chytrid fungus and Ranaviruses. Nasco has chosen to be pro-active and has tested our frog colony in advance of the mandated regulations.

Children with DiGeorge syndrome often have facial defects that include an   undeveloped chin, heavy eyelids, and ears that are rotated back. To   understand how genes cause DiGeorge syndrome's complex developmental problems, researchers have turned to z

Zebrafish Show How Genes Affect Facial Development

September 29, 2014 12:32 pm | by Harrison Wein, NIH | News | Comments

Children with DiGeorge syndrome often have facial defects that include an undeveloped chin, heavy eyelids, and ears that are rotated back. To understand how genes cause DiGeorge syndrome's complex developmental problems, researchers have turned to zebrafish as a model.

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A spice commonly found in curries may boost the brain's ability to heal itself. A German study suggests a compound found in turmeric could encourage the growth of nerve cells thought to be part of the brain's repair kit.

Tumeric Boosts Brain Repair in Rats

September 29, 2014 12:04 pm | by Smitha Mundasad, BBC | News | Comments

A spice commonly found in curries may boost the brain's ability to heal itself. A German study suggests a compound found in turmeric could encourage the growth of nerve cells thought to be part of the brain's repair kit.         

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Physical exercise has many beneficial effects on human health, including the protection from stress-induced depression. However, until now the mechanisms that mediate this protective effect have been unknown.

Well-muscled Mice Protect Their Brains from Stress-induced Depression

September 29, 2014 11:37 am | by Karolinska Institutet | News | Comments

Physical exercise has many beneficial effects on human health, including the protection from stress-induced depression. However, until now the mechanisms that mediate this protective effect have been unknown.           

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A triple-punch of antibodies both prevented hepatitis C infection and wiped out the disease after it had established itself in laboratory mice. Instead of delivering the three antibodies directly, researchers administered a genetic "instruction set" that,

Genetic Antibody Instructions Knock Down Hepatitis C in Mice

September 29, 2014 11:02 am | by Princeton Univ. | News | Comments

A triple-punch of antibodies both prevented hepatitis C infection and wiped out the disease after it had established itself in laboratory mice. Instead of delivering the three antibodies directly, researchers administered a genetic "instruction set" that, once in a cell, developed into antibodies that target the portions of the virus that do not mutate.

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Coulbourn Instruments' Small Animal Treadmills are ideal for forced exercise training and muscle fatigue studies in rodents. Benefits include reduced stress to subjects and smooth operation with the high performance, silent motor, even at high speeds.

Small Animal Treadmill

September 29, 2014 8:30 am | Harvard Apparatus | Product Releases | Comments

Coulbourn Instruments' Small Animal Treadmills are ideal for forced exercise training and muscle fatigue studies in rodents. Benefits include reduced stress to subjects and smooth operation with the high performance, silent motor, even at high speeds.

Look for the New ALN!

September 29, 2014 12:00 am | by Elizabeth Doughman | News | Comments

Check your mailbox for the new ALN Magazine! With this redesign, we are now able to better serve you, our readers. One of the new things the October issue of ALN will feature is fresh, current content and columns.                     

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