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The Lead

Seven Steps to Conflict Resolution

May 29, 2015 | by Martin Seidenfeld, Ph.D. | Articles | Comments

You can’t quite put your finger on it, but you sense a strange kind of tension in the workplace. It’s nothing overt. It’s just that people seem to be quieter, a bit on edge. The atmosphere is heavy. You see a decreased level of teamwork and a generally lowered level of morale. The lab seems to lack the aura of lightness that was its natural state. You had better find out what’s going on.



Why the Y Chromosome Matters

May 29, 2015 10:34 am | News | Comments

Several genes have been lost from the Y chromosome in humans and other mammals, according to research published in the open access journal Genome Biology. The study shows that essential Y genes are rescued by relocating to other chromosomes, and it identifies a potentially important genetic factor in male infertility.


Small Animal Radiation Therapy

May 28, 2015 3:08 pm | by Precision Xray Inc. | Product Releases | Comments

X-RAD SmART provides high accuracy imaging combined with an X-ray dose rate. Researchers can image in multiple imaging modalities, plan and treat without repositioning the specimen

Young Investigator Travel Award

May 28, 2015 2:22 pm | by Kent Scientific Corporation | Kent Scientific Corporation | Product Releases | Comments

We are offering two lucky people the opportunity to win the Young Investigator Travel Award to attend either Neuroscience 2015 in Chicago, IL or National AALAS 2015 in Phoenix, AZ. Winners will be awarded $1,500 to cover travel and registration costs of the conventions. Click here for the details!


A Robot that Can Perform Brain Surgery on a Fruit Fly

May 28, 2015 10:54 am | by John Markoff, The New York Times | News | Comments

On a small darkened platform a handful of fruit flies wander aimlessly. There is a brief flash of light and a robotic arm darts downward, precisely targeting a fly’s thorax, a moving target roughly the size of a pinhead. The fly seems unfazed, appearing not to notice that it has been snatched by a high-speed laboratory robot.


How the Upgraded Zebrafish Facility at Boston Children's Will Boost Drug Research

May 28, 2015 10:46 am | by Don Seiffert, Boston Business Journal | News | Comments

For 20 years, Leonard Zon has been a pioneer in drug research at Boston Children’s Hospital based on a one inch-long sea animal known as the zebrafish. Today, Zon and the hospital showcased a $4 million upgrade to the hospital’s zebrafish facility, thanks to the Massachusetts Life Sciences Center, which will ensure the region stays at the forefront of such research for years to come.


Transcription Factors Induce Growth of Sensory Hair Cells in the Ear

May 28, 2015 10:36 am | News | Comments

Scientists have developed a simple and efficient protocol to generate inner ear hair cells, the cells responsible for our hearing and sense of balance, using mice stem cells. This study is an important step for the future production of large numbers of these cells for use in cell transplantation therapies or large-scale drug screens.


Disruption During Early Embryogenesis in Zebrafish Leads to Autism Spectrum Disorder

May 28, 2015 10:25 am | News | Comments

Researchers are utilizing animal models to understand how dysfunction of either of two genes associated with ASD, SYNGAP1 and SHANK 3, contributes to risk in ASD. The new findings pinpoint the actual place and time where these genes exert influence in brain development and function. The findings are published in the journal Human Molecular Genetics.


Designing and Managing the LIMS at PRBB's Animal Facility

May 28, 2015 10:01 am | by Helen Kelly | Articles | Comments

Today's LIMS allow research institutions to monitor and manage a broad array of biomedical research processes end to end and remotely. But how do they accommodate tens of thousands of animals, the ongoing flood of discoveries in such as genetics, the -omics, regenerative medicine and behavior, ongoing adjustments to workflows and protocols, and the evolution of legislative, welfare quality, and ethics directives?


Nest Building Bedding

May 27, 2015 5:26 pm | by Shepherd Specialty Papers | Shepherd Specialty Papers | Product Releases | Comments

By providing mice with materials that stimulate their natural instincts, they forage, gather and build nests similar to those built by their wild counterparts.

Animal Study Identifies Possible Role for Carbon Monoxide in Treating Hemorrhagic Stroke

May 27, 2015 11:49 am | News | Comments

Carbon monoxide is known by many as a poisonous gas that causes brain injury and other neurological symptoms, including memory loss and confusion. But a new study suggests the opposite may be true: When administered in small, carefully controlled amounts, carbon monoxide may actually protect the brain from damage following subarachnoid hemorrhage, a devastating stroke that results from bleeding in the brain.


Changes in DNA During Withdrawal Spur Treatments for Addiction in Rats

May 27, 2015 11:21 am | News | Comments

One of the major challenges of cocaine addiction is the high rate of relapse after periods of withdrawal and abstinence. But new research reveals that changes in our DNA during drug withdrawal may offer promising ways of developing more effective treatments for addiction.


Nanotechnology Identifies Brain Tumor Types Through MRI "Virtual Biopsy" in Animal Studies

May 27, 2015 10:29 am | News | Comments

Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through "virtual biopsies" and then attack the molecular structure of the disease. If laboratory research with mice is borne out in human studies, the results could be used to deliver nano-scale drugs that can distinguish and fight tumor cells in the brain without resorting to surgery.


Researchers Grow Human Cancer Cells in Mouse Colon

May 27, 2015 10:16 am | by Anne Ju, Cornell University | News | Comments

Every day, it seems, someone in some lab is “curing cancer.” Well, it’s easy to kill cancer cells in a lab, but in a human, it’s a lot more complicated, which is why nearly all cancer drugs fail clinical trials. Taking steps to bridge this divide, researchers have created a comprehensive mouse model of exactly how colorectal tumors behave in real life - not just in a petri dish.


Removing Mutant P53 Significantly Improves Cancer Survival in Mouse Model

May 27, 2015 10:07 am | News | Comments

Removing accumulated mutant p53 protein from a cancer model showed that tumors regress significantly and survival increases. This finding, by an international team of cancer researchers, is reported in a paper published advanced online May 25 in Nature.


Rodents Are the Most Commonly Used Research Model in the Vivarium

May 27, 2015 9:49 am | by Elizabeth Doughman, Editor-in-Chief | Articles | Comments

Rodents, such as mice, rats and guinea pigs, are the most popular animal model used in the vivarium, according to a February 2015 ALN survey. Eighty-six percent of respondents indicated that they currently work with rodents. This number was more than double any of the other animal models used in the vivarium. Click here to view the rest of the results.



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