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Exposure to 'Auntie' Mouse Reverses Autism Deficits

November 26, 2014 | by Sarah DeWeerdt, SFARI | News | Comments

Over the past decade, some researchers have been tirelessly testing the effectiveness of early behavioral interventions for autism. Others have been hard at work characterizing and manipulating mouse models of the disorder. Growing up with an ‘auntie’ mouse reverses social and cognitive deficits seen in mice that model one of the most common forms of autism.

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Two-Cell Mouse Embryos Discuss Their Future

November 26, 2014 11:21 am | News | Comments

Bioengineers ahave discovered that mouse embryos are contemplating their cellular fates in the earliest stages after fertilization when the embryo has only two to four cells, a discovery that could upend the scientific consensus about when embryonic cells begin differentiating into cell types. Their research used single-cell RNA sequencing to look at every gene in the mouse genome.

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Funding Opportunity for Minor Use/Minor Species (MUMS) Development of Drugs to Publish in Early 2015

November 25, 2014 10:22 am | News | Comments

The Food and Drug Administration (FDA) will publish a New Funding Opportunity Announcement (FOA) entitled “Minor Use Minor Species Development of Drugs; Research Project Grant (R01)” in early 2015. The new FOA will replace #RFA-FD-12-003, which is set to expire on January 17, 2015.

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Orexin May be Key for Alzheimer's Prevention

November 25, 2014 10:19 am | by Michael C. Purdy | News | Comments

A protein that stimulates the brain to awaken from sleep may be a target for preventing Alzheimer’s disease, a study by researchers at Washington University School of Medicine in St. Louis suggests.           

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Motor Coordination Issues in Autism Caused by Abnormal Neural Connections

November 25, 2014 10:02 am | News | Comments

Using a mouse model of autism, scientists from the University of Chicago identified a malfunctioning neural circuit associated with reduced capacity for motor learning. This appears to arise from an inability to eliminate unneeded neural connections in the brain.

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Mitochondrial Fission Provides Possible Treatment for Parkinson's

November 25, 2014 9:33 am | by Harrison Wein, Ph.D. | News | Comments

Recent studies have linked dysfunctional mitochondria as one of the pathways causing neuron death. These organelles convert compounds derived from food into the molecules that cells use for energy. Studies suggest that proteins involved in the dynamics of these organelles may play a role in Parkinson’s disease.

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How to Ace Your Performance Review

November 25, 2014 9:23 am | Articles | Comments

Typically, managers dread having to perform employee assessments and experience high anxiety anticipating them. For the employee, too, who is about to undergo a formal performance assessment, the procedure is a high-anxiety producer. So what typically happens is that two very nervous people get together, try to act calm, and just “get through it.” It doesn’t have to be that way.

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What is the Current Status of Your Vivarium?

November 25, 2014 9:23 am | by Elizabeth Doughman | Articles | Comments

ALN recently asked readers what the current status of their vivarium was. Click through to see the results.                                               

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Sporicidal Disinfectant and Cleaner

November 25, 2014 9:20 am | Product Releases | Comments

PeridoxRTU is a ready-to-use-, broad spectrum EPA-registered sporicide, bactericide, virucide, tuberculocide and fungicide disinfectant and cleaner which contains no alcohol or bleach. PeridoxRTU is a proprietary chemistry which combines hydrogen peroxide and peracetic acid with proprietary ingredients to dramatically out-perform similar chemistries on the market. Peridox disinfectant and hard surface cleaner has a 3-minute sporicidal claim, a 2-minute virucidal and bactericidal claim, and a 1-minute fungicide claim with a chemistry that leaves minimal residue on surfaces. PeridoxRTU is now available validated sterile, for cleaning and disinfecting in sterile core areas.

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Eco-friendly Floor Covering

November 25, 2014 9:16 am | nora systems, Inc. | Product Releases | Comments

noraplan eco, an eco-friendly, economical floor covering uses recycled materials to create a smooth, high-performance floor covering that features a two-tone randomly scattered color chip pattern. More than 86 million square feet of the popular flooring have been sold since its introduction in 1999 for use in a variety of applications including healthcare, and education, such as Medical Center East in Birmingham, AL, Boone County Schools in Kentucky, and Grand Valley Schools in Ohio. Now available in 16 colors.

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8th Zebrafish Disease Models Conference

November 24, 2014 2:43 pm | Events

Boston, MA colm@conferencepartners.ie

Bone Marrow Stem Cells and Antioxidants Treat Brain Injuries in Mice

November 24, 2014 11:34 am | News | Comments

For the first time, researchers transplanted bone marrow stem cells into damaged brain tissue while applying lipoic acid (a potent antioxidant), with the aim of improving neuroregeneration in the tissue. This method of repairing brain damage, which combines cellular treatment with drug therapy, has shown positive results, especially in forming blood vessels in damaged areas of the brains of adult laboratory mice.

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Poor Serotonin Regulation Responsible for Anxiety Disorders

November 24, 2014 11:18 am | News | Comments

A lot of research has shown that poor regulation of the serotonin system, caused by certain genetic variations, can increase the risk of developing psychiatric illnesses such as autism, depression, or anxiety disorders.      

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Schizophrenia May Be Triggered By Excess Protein

November 24, 2014 10:55 am | by Robin Lally | News | Comments

A gene associated with schizophrenia plays a role in brain development and may help to explain the biological process of the disease, according to new Rutgers research.               

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Dried Blood Spot Analysis

November 24, 2014 10:50 am | by Heather DePietro, LVT, RLATg, Diana Medina, LVT, RLATg, and Gordon Roble, DVM, DACLAM | Articles | Comments

While blood draws are critical to monitoring biosecurity or mouse health, they induce stress in mice that can be seen through facial expressions and behavioral patterns. Previous studies have shown that certain bleeding techniques, such as sampling from the tail vein or using blood-sucking bugs, reduce stress. The recently developed dried blood spot (DBS) analysis method may further reduce stress, regardless of sampling technique.

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Emergency Laboratory Safety Shower Decontamination Booth

November 24, 2014 10:23 am | Hemco | Product Releases | Comments

These Emergency Shower / Decontamination Booths are fully assembled and ready for installation to water supply and waste systems. The shower is molded in a one piece seamless chemical resistant fiberglass and is equipped with a pull rod activated shower and push handle eye/face wash for immediately drenching of personnel that have been exposed to hazardous chemicals. Shower is equipped with frosted front strip curtains, interior grab bars, raised deck grating, and bottom or rear drain outlet. Compliant with A.N.S.I. and O.S.H.A. requirements.

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