You can’t quite put your finger on it, but you sense a strange kind of tension in the workplace. It’s nothing overt. It’s just that people seem to be quieter, a bit on edge. The atmosphere is heavy. You see a decreased level of teamwork and a generally lowered level of morale. The lab seems to lack the aura of lightness that was its natural state. You had better find out what’s going on.
Is it possible to tap into the signaling in the brain to figure out where you will go next? A...
Our environment can have a major impact on how we develop, and it turns out it’s no different...
Several genes have been lost from the Y chromosome in humans and other mammals, according to research published in the open access journal Genome Biology. The study shows that essential Y genes are rescued by relocating to other chromosomes, and it identifies a potentially important genetic factor in male infertility.
X-RAD SmART provides high accuracy imaging combined with an X-ray dose rate. Researchers can image in multiple imaging modalities, plan and treat without repositioning the specimen
We are offering two lucky people the opportunity to win the Young Investigator Travel Award to attend either Neuroscience 2015 in Chicago, IL or National AALAS 2015 in Phoenix, AZ. Winners will be awarded $1,500 to cover travel and registration costs of the conventions. Click here for the details!
On a small darkened platform a handful of fruit flies wander aimlessly. There is a brief flash of light and a robotic arm darts downward, precisely targeting a fly’s thorax, a moving target roughly the size of a pinhead. The fly seems unfazed, appearing not to notice that it has been snatched by a high-speed laboratory robot.
For 20 years, Leonard Zon has been a pioneer in drug research at Boston Children’s Hospital based on a one inch-long sea animal known as the zebrafish. Today, Zon and the hospital showcased a $4 million upgrade to the hospital’s zebrafish facility, thanks to the Massachusetts Life Sciences Center, which will ensure the region stays at the forefront of such research for years to come.
Scientists have developed a simple and efficient protocol to generate inner ear hair cells, the cells responsible for our hearing and sense of balance, using mice stem cells. This study is an important step for the future production of large numbers of these cells for use in cell transplantation therapies or large-scale drug screens.
Researchers are utilizing animal models to understand how dysfunction of either of two genes associated with ASD, SYNGAP1 and SHANK 3, contributes to risk in ASD. The new findings pinpoint the actual place and time where these genes exert influence in brain development and function. The findings are published in the journal Human Molecular Genetics.
Today's LIMS allow research institutions to monitor and manage a broad array of biomedical research processes end to end and remotely. But how do they accommodate tens of thousands of animals, the ongoing flood of discoveries in such as genetics, the -omics, regenerative medicine and behavior, ongoing adjustments to workflows and protocols, and the evolution of legislative, welfare quality, and ethics directives?
By providing mice with materials that stimulate their natural instincts, they forage, gather and build nests similar to those built by their wild counterparts.
Carbon monoxide is known by many as a poisonous gas that causes brain injury and other neurological symptoms, including memory loss and confusion. But a new study suggests the opposite may be true: When administered in small, carefully controlled amounts, carbon monoxide may actually protect the brain from damage following subarachnoid hemorrhage, a devastating stroke that results from bleeding in the brain.
One of the major challenges of cocaine addiction is the high rate of relapse after periods of withdrawal and abstinence. But new research reveals that changes in our DNA during drug withdrawal may offer promising ways of developing more effective treatments for addiction.
Biomedical researchers at Cedars-Sinai have invented a tiny drug-delivery system that can identify cancer cell types in the brain through "virtual biopsies" and then attack the molecular structure of the disease. If laboratory research with mice is borne out in human studies, the results could be used to deliver nano-scale drugs that can distinguish and fight tumor cells in the brain without resorting to surgery.
Every day, it seems, someone in some lab is “curing cancer.” Well, it’s easy to kill cancer cells in a lab, but in a human, it’s a lot more complicated, which is why nearly all cancer drugs fail clinical trials. Taking steps to bridge this divide, researchers have created a comprehensive mouse model of exactly how colorectal tumors behave in real life - not just in a petri dish.
Removing accumulated mutant p53 protein from a cancer model showed that tumors regress significantly and survival increases. This finding, by an international team of cancer researchers, is reported in a paper published advanced online May 25 in Nature.
Rodents, such as mice, rats and guinea pigs, are the most popular animal model used in the vivarium, according to a February 2015 ALN survey. Eighty-six percent of respondents indicated that they currently work with rodents. This number was more than double any of the other animal models used in the vivarium. Click here to view the rest of the results.