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Q&A: CROs in Asia

April 27, 2015 | by Elizabeth Doughman, Editor-in-Chief | Articles | Comments

This week's Tales From the Lab is Sandra Burlock. She is the Director of Technician Operations at Wuxi AppTec Co., Ltd. in Suzhou, China. Sandra is originally from New Brunswick, Canada.

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Live Imaging Tells Researchers How Taste Works

April 27, 2015 3:55 pm | by Elizabeth Doughman, Editor-in-Chief | News | Comments

For the first time, an international team of scientists have captured live images of the process of taste on the tongue of a mouse with a specially designed microscope system. The images may lead to discoveries that could help in dietary disorders.

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In a new study, researchers have made insights into how the blood-brain barrier, or BBB, is maintained, identifying a protein key to the process. Delivering this protein to mice with the rodent equivalent of MS improved their symptoms.

How Blood-Brain Barrier is Maintained

April 27, 2015 10:56 am | by University of Pennsylvania | News | Comments

In a new study, researchers have made insights into how the blood-brain barrier, or BBB, is maintained, identifying a protein key to the process. Delivering this protein to mice with the rodent equivalent of MS improved their symptoms.

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A team of international scientists has identified hundreds of possible new genes in mice that could transform benign skin growths into deadly melanomas.

Hundreds of Cancer Possibilities Arise From Common Skin Mole Mutation

April 27, 2015 10:37 am | News | Comments

A team of international scientists has identified hundreds of possible new genes in mice that could transform benign skin growths into deadly melanomas.

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Researchers have pinpointed a molecular link between DNA damage, cellular senescence and premature aging. Finding the key players could lead to therapeutic targets for counteracting some of the negative effects of progerias and perhaps even forestalling t

Molecular Link Between DNA Damage and Premature Aging Identified in Mice

April 27, 2015 10:13 am | by University of Pennsylvania | News | Comments

Researchers have pinpointed a molecular link between DNA damage, cellular senescence and premature aging. Finding the key players could lead to therapeutic targets for counteracting some of the negative effects of progerias and perhaps even forestalling the effects of natural aging.

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New Finding Could Help Develop Test for Kidney Failure

April 24, 2015 10:51 am | News | Comments

Scientists at The University of Manchester have made an important finding that could help develop an early test for kidney disease.

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Storage Method Could Improve Organ Transplantation Odds

April 24, 2015 10:40 am | News | Comments

People waiting for organ transplants may soon have higher hopes of getting the help that they need in time. Researchers have developed a new technique that extends the time that donor organs last and can also resuscitate organs obtained after cardiac arrest.

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Nanoparticle Drug Reverses Parkinson's-like Symptoms in Rats

April 24, 2015 10:24 am | News | Comments

As baby boomers age, the number of people diagnosed with Parkinson's disease is expected to increase. Patients who develop this disease usually start experiencing symptoms around age 60 or older. Currently, there's no cure, but scientists are reporting a novel approach that reversed Parkinson's-like symptoms in rats. Their results, published in the journal ACS Nano, could one day lead to a new therapy for human patients.

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Gene Associated with Rare Disease Determines How Body Processes Pain

April 24, 2015 10:13 am | News | Comments

The researched studied the way neural circuits transform harmful stimuli into the perception of pain. More precisely, it examined the gene Lmx1b and its involvement in pain processing. Mutations in this gene also cause a rare human disease called the Nail-patella syndrome (NPS), which is characterized by limb and kidney malformations. More importantly, NPS patients show reduced pain responses.

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Porcine Study Aimed at Engineering More Natural and Durable Replacement Heart Valves

April 24, 2015 9:51 am | News | Comments

With a $450,000 grant from the National Institutes of Health and using porcine cell valves, researchers at Worcester Polytechnic Institute will analyze how mechanical forces and cellular growth factors affect the growth and development of human heart valves to advance the long-term goal of using tissue engineering to develop replacement valves that are more natural and longer-lasting than current replacement valves.

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Using Positive Reinforcement to Motivate Employees

April 24, 2015 9:38 am | by Martin Seidenfeld, Ph.D. | Articles | Comments

You’ve probably heard it many times, the command to “catch ‘em doing something right!” There’s a good reason this has become a common catchphrase. It’s because “catching” your employee doing something right—performing well—provides a golden opportunity for you to reinforce that “right” behavior.

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Protein that Serves a Brake on Inflammation Identified

April 23, 2015 10:44 am | News | Comments

Researchers have identified a protein that offers a new focus for developing targeted therapies to tame the severe inflammation associated with multiple sclerosis (MS), colitis, and other autoimmune disorders. St. Jude Children’s Research Hospital scientists led the study which appears this week in the scientific journal Immunity.

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Immune System Protein Regulates Sensitivity to Bitter Taste

April 23, 2015 10:30 am | News | Comments

New research from the Monell Center reveals that tumor necrosis factor (TNF), an immune system regulatory protein that promotes inflammation, also helps regulate sensitivity to bitter taste. The finding may provide a mechanism to explain the taste system abnormalities and decreased food intake that can be associated with infections, autoimmune disorders, and chronic inflammatory diseases.

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Contec, Inc. Awarded for Outstanding Safety Practices

April 23, 2015 10:15 am | Contec, Inc. | News | Comments

Contec, Inc. was recently awarded a 2015 Certificate of Safety Achievement by the State of South Carolina’s Labor, Licensing, and Regulation Department “for outstanding efforts in the promotion of Industrial Safety and Health, with such efforts resulting in the lessening of human suffering and the reduction of economic waste 1.2 million hours without a lost time injury or illness”.

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Maternal Stress Increases Development of Fetal Neuroblastoma in Mice

April 23, 2015 10:12 am | News | Comments

While genetics play a substantial role in development of neuroblastoma, scientists say that something else is in play that elevates the risk: stress. Researchers from the Georgetown University Medical Center have shown in mice genetically predisposed to develop neuroblastoma that maternal stress can push onset of the cancer.

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Omission Cues Suppress Relapse in Animal Models of Drug Addiction

April 23, 2015 10:04 am | News | Comments

A new study is researching the brain mechanisms behind the cues signaling the unavailability of drugs or alcohol (“omission cues”) that can actually suppress relapse in well-established animal models of drug addiction. This research could not only uncover fundamental workings of the brain in behavioral inhibition, but could also point to new methods for helping people resist relapse.

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