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Why Employees Quit: Frustration about Resources

October 23, 2014 | Articles | Comments

When someone says I don’t like my job, there’s little hope of retaining that employee, right? Not necessarily, there’s a fair chance that I don’t like my job reflects feelings of discontent rather than a clear picture of dissatisfaction, and a decision to leave would be premature. In the next few weeks, we'll cover common employee complaints and suggestions on how to address these issues. Up this week: frustration about lack of resources.

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Blind Cave Fish May Provide Insight on Eye Disease

October 23, 2014 11:46 am | News | Comments

Blind cave fish may not be the first thing that comes to mind when it comes to understanding human sight, but recent research indicates they may have quite a bit to teach us about the causes of many human ailments, including those that result in loss of sight. A team of researchers is looking to the tiny eyeless fish for clues about the underpinnings of degenerative eye disease and more.

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David and Barbara Roux Provide $10 Million Gift For Genomic Medicine Research at JAX

October 23, 2014 11:27 am | The Jackson Laboratory | News | Comments

The Jackson Laboratory (JAX) has announced that technology investor David Roux and his wife Barbara have gifted $10 million to support research and find cures for genetically based diseases. The center will be based at the Laboratory’s locations in both Maine and Connecticut.

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Drug Inhibits Tumor Growth in Mice

October 23, 2014 11:08 am | News | Comments

A new drug, known as OTS964, can eradicate aggressive human lung cancers transplanted into mice. The drug, given as a pill or by injection, inhibits the action of a protein that is overproduced by several tumor types, including lung and breast, but is rarely expressed in healthy adult tissues. Without this protein, cancer cells fail to complete the cell-division process and die.

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Ventilated Euthanasia Station

October 23, 2014 10:52 am | AFOS, Ltd. | Product Releases | Comments

 The AFOS ventilated euthanasia station provides a fully sealed, controllable and fast process for euthanasia and surgery induction.

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Hidden Subpopulation of Melanoma Cells Discovered

October 22, 2014 12:23 pm | News | Comments

UNC School of Medicine researchers have pinpointed a set of intriguing characteristics in a previously unknown subpopulation of melanoma cancer cells in blood vessels of tumors. These cells, which mimic non-cancerous endothelial cells that normally populate blood vessels in tumors, could provide researchers with another target for cancer therapies.

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Protecting Us From Our Cells

October 22, 2014 12:06 pm | News | Comments

Our immune system defends us from harmful bacteria and viruses, but, if left unchecked, the cells that destroy those invaders can turn on the body itself, causing auto-immune diseases like type-1 diabetes or multiple sclerosis. A molecule called insulin-like growth factor-1 boosts the body’s natural defense against this ‘friendly fire.’

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Noise-Deafened Mice Hear Again

October 22, 2014 11:46 am | News | Comments

Scientists have restored hearing in noise-deafened mice, pointing way to new therapies for humans. The research team shows the key role of protein called NT3 in ear-to-brain communication. These findings pave the way for research in humans that could improve treatment of hearing loss caused by noise exposure and normal aging.

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Focusing In on a Decades Old Mystery

October 21, 2014 11:41 am | News | Comments

Elvis did it, Michael Jackson did it, and so do the mitochondria in our cells. They shake. While Elvis and Michael shook for decades before loud and appreciative audiences, mitochondrial oscillations have quietly bewildered scientists for more than 40 years. Now, an NIH team has imaged mitochondria for the first time oscillating in a live animal - in this case, the salivary glands of laboratory rats.

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Huntington's Study Halted Due to Rat Results

October 21, 2014 11:27 am | News | Comments

A biopharmaceutical company has suspended its Huntington's disease clinical trial as it further evaluates an observation from a nonclinical study in rats. Non-human primates exposed to plasma concentrations equal to those in the rat demonstrated no findings similar to the observation reported from the rat study.

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Antibiotics May Increase Spread of Salmonella

October 21, 2014 11:13 am | by Bruce Goldman, Stanford University School of Medicine | News | Comments

Salmonella-infected mice that were given antibiotics became sicker and began shedding far more bacteria in their feces than they had before. But some “superspreader” mice remained healthy, unaffected by either the disease or the antibiotic. The study poses ominous questions about the widespread, routine use of sub-therapeutic doses of antibiotics in livestock.

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Medical Imaging Detects Early Cancer in Lab Mice

October 21, 2014 10:15 am | News | Comments

A new medical imaging method could help physicians detect cancer and other diseases earlier than before, speeding treatment and reducing the need for invasive, time-consuming biopsies. The potentially lifesaving technique uses nanotechnology to reveal small cancerous tumors and cardiovascular lesions deep inside the body. The researchers have demonstrated positive results in laboratory mice.

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Rat Study Helps to Understand Epilepsy, Other Brain Disorders

October 21, 2014 12:00 am | News | Comments

Researchers have used graphene, a two-dimensional form of carbon only one atom thick, to fabricate a new type of microelectrode that solves a major problem for investigators looking to understand the intricate circuitry of the brain. The team performed calcium imaging of hippocampal slices in a rat model with both confocal and two-photon microscopy, while also conducting electrophysiological recordings.

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Therapeutic Saline May Treat Alzheimer's Disease, Other Dementias

October 20, 2014 12:33 pm | News | Comments

Revalesio Corp. and Rush University Medical Center's Department of Neurological Sciences have published findings from two research studies that demonstrate the potential for RNS60 to treat Alzheimer's disease and other forms of dementia by protecting neuronal function, restoring neuronal connections and promoting neuronal plasticity.

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Drug May Offer Alternative to Chemo for Blood Cancer

October 20, 2014 12:20 pm | News | Comments

Researchers say that blocking the action of an enzyme “switch” needed to activate tumor growth is emerging as a practical strategy for treating T-cell acute lymphoblastic leukemia. An estimated quarter of the 500 U.S. adolescents and young adults diagnosed each year with this aggressive disease fail to respond to standard chemotherapy drugs that target cancer cells.

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Mature Human Intestinal Tissue Formed in Mice

October 20, 2014 12:13 pm | News | Comments

Researchers have successfully transplanted “organoids” of functioning human intestinal tissue grown from pluripotent stem cells in a lab dish into mice – creating an unprecedented model for studying diseases of the intestine. The findings could eventually lead to bioengineering personalized human intestinal tissue to treat gastrointestinal diseases.

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