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The Lead

Critical Care Management for Laboratory Mice and Rats

April 16, 2014 8:13 am | by F.Claire Hankenson, DVM, MS, Diplomate ACLAM | Articles | Comments

For critical care of laboratory rodents, there is a scarcity of sources that provide comprehensive, feasible, and response-oriented information about clinical interventions specific to spontaneous and induced models of disease. Critical care monitoring for small rodent patients is notoriously challenging, complicated further by physiologic idiosyncracies and limitations on applicable treatments and interventions."



Technique Reverse-engineers Developing Lung

April 16, 2014 1:08 pm | by Tom Abate, Stanford Univ. | News | Comments

In a feat of reverse tissue engineering, researchers have begun to unravel the complex genetic coding that allows embryonic cells to proliferate and transform into all of the specialized cells that perform a myriad of different biological tasks.  


Hair from Infant Monkeys Gives Clues about Life in the Womb

April 16, 2014 12:36 pm | by Kelly April Tyrrell, Univ. of Wisconsin-Madison | News | Comments

A team researchers show in a study of rhesus monkeys that hair can reveal the womb environment in which an infant formed.                                     


Mouse Model Would Have Predicted Toxicity of Fatal Drug

April 16, 2014 12:22 pm | by PLOS | News | Comments

Over 20 years after the fatal fialuridine trial, a study demonstrates that mice with humanized livers recapitulate the drug's toxicity.                                 


Environmental Chambers

April 16, 2014 8:14 am | TSE Systems, Inc. | Product Releases | Comments

These environmental chambers for animals are designed in close collaboration with top researchers to provide accurate and reliable control over temperature, humidity, and lighting conditions for experimental setup and animal welfare.


Researchers Transplant Regenerated Esophagus in Rats

April 15, 2014 2:09 pm | by Karolinska Institutet | News | Comments

Tissue engineering has been used to construct natural esophagi, which in combination with bone marrow stem cells have been safely and effectively transplanted in rats.                        


Age Matters for Regenerating Muscle in Duchenne MS Models

April 15, 2014 1:29 pm | by Susan Gammon, Sanford-Burnham Medical Research Institute | News | Comments

A team of scientists have published details of how a class of drugs called “HDACis” drive muscle-cell regeneration in the early stages of dystrophic muscles, but fail to work in late stages.                 


Finding Where Memory Begins

April 15, 2014 1:04 pm | by Latarsha Gatlin, Johns Hopkins Univ. | News | Comments

By tracking brain activity when an animal stops to look around its environment, neuroscientists believe they can mark the birth of a memory.                               


Register for the 2014 TurnKey Conference and Enter to Win a $1,000 Travel Voucher

April 15, 2014 10:55 am | News | Comments

One lucky attendee at this year’s TurnKey Conference will receive a $1,000 travel voucher to TurnKey 2015 to be held in San Diego!  The drawing will be held and the winner announced during the 2014 Conference, held May 13-14 at the Gaylord National Hotel in MD.  Winner must be present to win. 


Quad Isolator

April 15, 2014 8:22 am | Class Biologically Clean, Ltd. | Product Releases | Comments

This quad, positive pressure, flexible film isolator features four independent isolators in one footprint.


A Bestiary of Difficult Employees and How to Deal With Them: Billygoats

April 15, 2014 8:16 am | Articles | Comments

For the next few weeks, we'll present you with a list of commonly found “beastly” employees, with descriptions of their behavior and suggested strategies for coping with them. Billygoats respond to every idea with “it won’t work.” They always feel there’s nothing they can do, believe they have no power over their own lives. At group meetings they create a sense of helplessness.


Kenneth B Macleod August 23rd 1952 – March 26th 2014

April 14, 2014 4:19 pm | News | Comments

It is with great sorrow that ALN marks the passing of Ken Macleod. Ken leaves to mourn his wife Meg and their children. He will be sadly missed but never forgotten by his many friends and business associates.         

Stress Damage Blocked in Mice

April 14, 2014 2:08 pm | by Bill Hathaway, Yale Univ. | News | Comments

Ketamine, an anesthetic sometimes abused as a street drug, increases the synaptic connections between brain cells and in low doses acts as a powerful antidepressant. However, stress has the opposite effect, shrinking the number of synaptic spines, triggering depression.


Kidney Regeneration Linked to Gene Found in Mice

April 14, 2014 1:50 pm | by Boston Children's Hospital | News | Comments

Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise for children with Wilms.     


Sensitive Immune System Balance Seen in Mice

April 14, 2014 1:39 pm | by Helmholtz Centre for Infection Research | News | Comments

In the presence of an excess of the protein c-FLIPR, mice can fight infectious diseases better, but they develop autoimmune diseases as they get older.                            


Mouse Model Could Revolutionize Alzheimer's Research

April 14, 2014 1:23 pm | by RIKEN | News | Comments

A group of researchers have reported the creation of two new mouse models of Alzheimer’s disease that may potentially revolutionize research into this disease.                          



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