To the BSL-3 practices we add requirements for complete clothing change before entry, a shower on exit, and decontamination of all materials prior to leaving the facility. The BSL-4 laboratory should contain a Class III biological safety cabinet but may use a Class I or II BSC in combination with a positive pressure, air-supplied full-body suit.
Research describes how introducing three proteins that control the regulation of DNA in the...
Mice used in research, unlike their human counterparts, can get pain relief from the glow of a...
A recent study in mice identifies increased levels of a specific neurotransmitter as a contributing factor connecting traumatic brain injury (TBI) to post-traumatic epilepsy.
A Japanese government-funded laboratory said it is considering retracting a research paper describing a simple way of turning ordinary cells from mice into stem cells.
Researchers found that aged mice lacking the antioxidant protein Nrf2 that underwent two weeks of endurance exercise stress on treadmills showed poor stem cell regeneration, which is likely to hinder the recovery of lost muscle mass.
Researchers say memory trouble doesn’t have to be inevitable, and they’ve found a drug therapy that could potentially reverse memory decline.
Researchers found that electroacupuncture in mice reduced the inflammation responsible for sepsis. The mechanisms underlying the therapy hint at new approaches to treat inflammatory disorders.
For the first time, researchers have shown that an essential biological process known as protein synthesis can be studied in adult stem cells — something scientists have long struggled to accomplish.
The TurnKey Conference, held May 13–14 in National Harbor, MD, is proud to announce that senior members of the National Institutes of Health (NIH) Division of Technical Resources (DTR) will be giving a presentation on the latest updates to the Design Requirements Manual.
In lab animal studies, we aim to reduce variability between groups by housing all of the animals in the same room, using the same number of animals per cage, and using the same water, bedding, enrichment, and diet. So, when experimental animals are fed a special diet, the control animals should be fed a diet matched in every way to the special diet, except, of course, for the dietary variable that the researcher is studying.
Mice are the most prevalent animal utilized within the biomedical field, and, in the early 1980s, the development of transgenic technologies which lead to the availability of genetically engineered mice further expanded their usefulness within fields of immunology, oncology, physiology, pathology, and neuroscience.
For critical care of laboratory rodents, there is a scarcity of sources that provide comprehensive, feasible, and response-oriented information about clinical interventions specific to spontaneous and induced models of disease. Critical care monitoring for small rodent patients is notoriously challenging, complicated further by physiologic idiosyncracies and limitations on applicable treatments and interventions."
This 4 cm freshwater fish, whose native range includes the Ganges and Brahmaputra River basins of India, Bangladesh, and Nepal, has undergone one of the widest dispersals (albeit anthropogenic) in possibly the shortest time frame of any vertebrate species, initially as a popular aquarium fish and in the last 30 years as a scientific research model.
Research institutions are large users of energy, construction materials, water, chemicals, and laboratory and vivarium equipment. Major universities and pharmaceutical companies across the globe implement procedures to ensure resource and energy efficiencies are practiced.
Studies have shown that the temperatures in the lab are too cold for rodents. Most labs are kept at a temperature that is most comfortable for lab employees and program budgets. Furthermore, studies have shown the abnormal behaviors and problems that arise when mice are not able to thermoregulate within the lab environment.
Humanely euthanizing rodents should be a concern for all facilities. Many institutions are still using a box connected via a hose directly to the CO2 tank. With the stricter AVMA guidelines released in 2013, this practice should already be eliminated.
Reelin, a crucial protein for adult brain plasticity, recovers cognitive functions in mice with Alzheimer’s disease.